Gene name: POLR2E

Uniprot entry:

P19388

Protein names:

DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)

Protein sequence:

1_MDDEE 6_ ETYRL 11_ WKIRK 16_ TIMQL 21_ CHDRG 26_ YLVTQ 31_ DELDQ 36_ TLEEF 41_ KAQSG 46_ DKPSE 51_ GRPRR 56_ TDLTV 61_ LVAHN 66_ DDPTD 71_ QMFVF 76_ FPEEP 81_ KVGIK 86_ TIKVY 91_ CQRMQ 96_ EENIT 101_ RALIV 106_ VQQGM 111_ TPSAK 116_ QSLVD 121_ MAPKY 126_ ILEQF 131_ LQQEL 136_ LINIT 141_ EHELV 146_ PEHVV 151_ MTKEE 156_ VTELL 161_ ARYKL 166_ RENQL 171_ PRIQA 176_ GDPVA 181_ RYFGI 186_ KRGQV 191_ VKIIR 196_ PSETA 201_GRYIT

Protein annotations

Protein functions:

1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template