Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
1_MGMSS 6_ LKLLK 11_ YVLFF 16_ FNLLF 21_ WICGC 26_ CILGF 31_ GIYLL 36_ IHNNF 41_ GVLFH 46_ NLPSL 51_ TLGNV 56_ FVIVG 61_ SIIMV 66_ VAFLG 71_ CMGSI 76_ KENKC 81_ LLMSF 86_ FILLL 91_ IILLA 96_ EVTLA 101_ ILLFV 106_ YEQKL 111_ NEYVA 116_ KGLTD 121_ SIHRY 126_ HSDNS 131_ TKAAW 136_ DSIQS 141_ FLQCC 146_ GINGT 151_ SDWTS 156_ GPPAS 161_ CPSDR 166_ KVEGC 171_ YAKAR 176_ LWFHS 181_ NFLYI 186_ GIITI 191_ CVCVI 196_ EVLGM 201_ SFALT 206_ LNCQI 211_DKTSQ
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:28487417). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:32974937, PubMed:35767951). Plays a role in the activation of monocytes and B-cells (PubMed:8335905). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (PubMed:28487417). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment (By similarity)