Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
1_MGLST 6_ VPDLL 11_ LPLVL 16_ LELLV 21_ GIYPS 26_ GVIGL 31_ VPHLG 36_ DREKR 41_ DSVCP 46_ QGKYI 51_ HPQNN 56_ SICCT 61_ KCHKG 66_ TYLYN 71_ DCPGP 76_ GQDTD 81_ CRECE 86_ SGSFT 91_ ASENH 96_ LRHCL 101_ SCSKC 106_ RKEMG 111_ QVEIS 116_ SCTVD 121_ RDTVC 126_ GCRKN 131_ QYRHY 136_ WSENL 141_ FQCFN 146_ CSLCL 151_ NGTVH 156_ LSCQE 161_ KQNTV 166_ CTCHA 171_ GFFLR 176_ ENECV 181_ SCSNC 186_ KKSLE 191_ CTKLC 196_ LPQIE 201_ NVKGT 206_ EDSGT 211_ TVLLP 216_ LVIFF 221_ GLCLL 226_ SLLFI 231_ GLMYR 236_ YQRWK 241_ SKLYS 246_ IVCGK 251_ STPEK 256_ EGELE 261_ GTTTK 266_ PLAPN 271_ PSFSP 276_ TPGFT 281_ PTLGF 286_ SPVPS 291_ STFTS 296_ SSTYT 301_ PGDCP 306_ NFAAP 311_ RREVA 316_ PPYQG 321_ ADPIL 326_ ATALA 331_ SDPIP 336_ NPLQK 341_ WEDSA 346_ HKPQS 351_ LDTDD 356_ PATLY 361_ AVVEN 366_ VPPLR 371_ WKEFV 376_ RRLGL 381_ SDHEI 386_ DRLEL 391_ QNGRC 396_ LREAQ 401_ YSMLA 406_ TWRRR 411_ TPRRE 416_ ATLEL 421_ LGRVL 426_ RDMDL 431_ LGCLE 436_ DIEEA 441_ LCGPA 446_ALPPA
1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase