Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)
1_MWLRS 6_ HRQLC 11_ LAFLL 16_ VCVLS 21_ VIFFL 26_ HIHQD 31_ SFPHG 36_ LGLSI 41_ LCPDR 46_ RLVTP 51_ PVAIF 56_ CLPGT 61_ AMGPN 66_ ASSSC 71_ PQHPA 76_ SLSGT 81_ WTVYP 86_ NGRFG 91_ NQMGQ 96_ YATLL 101_ ALAQL 106_ NGRRA 111_ FILPA 116_ MHAAL 121_ APVFR 126_ ITLPV 131_ LAPEV 136_ DSRTP 141_ WRELQ 146_ LHDWM 151_ SEEYA 156_ DLRDP 161_ FLKLS 166_ GFPCS 171_ WTFFH 176_ HLREQ 181_ IRREF 186_ TLHDH 191_ LREEA 196_ QSVLG 201_ QLRLG 206_ RTGDR 211_ PRTFV 216_ GVHVR 221_ RGDYL 226_ QVMPQ 231_ RWKGV 236_ VGDSA 241_ YLRQA 246_ MDWFR 251_ ARHEA 256_ PVFVV 261_ TSNGM 266_ EWCKE 271_ NIDTS 276_ QGDVT 281_ FAGDG 286_ QEATP 291_ WKDFA 296_ LLTQC 301_ NHTIM 306_ TIGTF 311_ GFWAA 316_ YLAGG 321_ DTVYL 326_ ANFTL 331_ PDSEF 336_ LKIFK 341_ PEAAF 346_ LPEWV 351_ GINAD 356_LSPLW
1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity)