Wilms tumor protein (WT33)
1_MGSDV 6_ RDLNA 11_ LLPAV 16_ PSLGG 21_ GGGCA 26_ LPVSG 31_ AAQWA 36_ PVLDF 41_ APPGA 46_ SAYGS 51_ LGGPA 56_ PPPAP 61_ PPPPP 66_ PPPHS 71_ FIKQE 76_ PSWGG 81_ AEPHE 86_ EQCLS 91_ AFTVH 96_ FSGQF 101_ TGTAG 106_ ACRYG 111_ PFGPP 116_ PPSQA 121_ SSGQA 126_ RMFPN 131_ APYLP 136_ SCLES 141_ QPAIR 146_ NQGYS 151_ TVTFD 156_ GTPSY 161_ GHTPS 166_ HHAAQ 171_ FPNHS 176_ FKHED 181_ PMGQQ 186_ GSLGE 191_ QQYSV 196_ PPPVY 201_ GCHTP 206_ TDSCT 211_ GSQAL 216_ LLRTP 221_ YSSDN 226_ LYQMT 231_ SQLEC 236_ MTWNQ 241_ MNLGA 246_ TLKGV 251_ AAGSS 256_ SSVKW 261_ TEGQS 266_ NHSTG 271_ YESDN 276_ HTTPI 281_ LCGAQ 286_ YRIHT 291_ HGVFR 296_ GIQDV 301_ RRVPG 306_ VAPTL 311_ VRSAS 316_ ETSEK 321_ RPFMC 326_ AYPGC 331_ NKRYF 336_ KLSHL 341_ QMHSR 346_ KHTGE 351_ KPYQC 356_ DFKDC 361_ ERRFS 366_ RSDQL 371_ KRHQR 376_ RHTGV 381_ KPFQC 386_ KTCQR 391_ KFSRS 396_ DHLKT 401_ HTRTH 406_ TGKTS 411_ EKPFS 416_ CRWPS 421_ CQKKF 426_ ARSDE 431_ LVRHH 436_ NMHQR 441_NMTKL
1: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921)