Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
1_MVLRS 6_ GICGL 11_ SPHRI 16_ FPSLL 21_ VVVAL 26_ VGLLP 31_ VLRSH 36_ GLQLS 41_ PTAST 46_ IRSSE 51_ PPRER 56_ SIGDV 61_ TTAPP 66_ EVTPE 71_ SRPVN 76_ HSVTD 81_ HGMKP 86_ RKAFP 91_ VLGID 96_ YTHVR 101_ TPFEI 106_ SLWIL 111_ LACLM 116_ KIGFH 121_ VIPTI 126_ SSIVP 131_ ESCLL 136_ IVVGL 141_ LVGGL 146_ IKGVG 151_ ETPPF 156_ LQSDV 161_ FFLFL 166_ LPPII 171_ LDAGY 176_ FLPLR 181_ QFTEN 186_ LGTIL 191_ IFAVV 196_ GTLWN 201_ AFFLG 206_ GLMYA 211_ VCLVG 216_ GEQIN 221_ NIGLL 226_ DNLLF 231_ GSIIS 236_ AVDPV 241_ AVLAV 246_ FEEIH 251_ INELL 256_ HILVF 261_ GESLL 266_ NDAVT 271_ VVLYH 276_ LFEEF 281_ ANYEH 286_ VGIVD 291_ IFLGF 296_ LSFFV 301_ VALGG 306_ VLVGV 311_ VYGVI 316_ AAFTS 321_ RFTSH 326_ IRVIE 331_ PLFVF 336_ LYSYM 341_ AYLSA 346_ ELFHL 351_ SGIMA 356_ LIASG 361_ VVMRP 366_ YVEAN 371_ ISHKS 376_ HTTIK 381_ YFLKM 386_ WSSVS 391_ ETLIF 396_ IFLGV 401_ STVAG 406_ SHHWN 411_ WTFVI 416_ STLLF 421_ CLIAR 426_ VLGVL 431_ GLTWF 436_ INKFR 441_ IVKLT 446_ PKDQF 451_ IIAYG 456_ GLRGA 461_ IAFSL 466_ GYLLD 471_ KKHFP 476_ MCDLF 481_ LTAII 486_ TVIFF 491_ TVFVQ 496_ GMTIR 501_ PLVDL 506_ LAVKK 511_ KQETK 516_ RSINE 521_ EIHTQ 526_ FLDHL 531_ LTGIE 536_ DICGH 541_ YGHHH 546_ WKDKL 551_ NRFNK 556_ KYVKK 561_ CLIAG 566_ ERSKE 571_ PQLIA 576_ FYHKM 581_ EMKQA 586_ IELVE 591_ SGGMG 596_ KIPSA 601_ VSTVS 606_ MQNIH 611_ PKSLP 616_ SERIL 621_ PALSK 626_ DKEEE 631_ IRKIL 636_ RNNLQ 641_ KTRQR 646_ LRSYN 651_ RHTLV 656_ ADPYE 661_ EAWNQ 666_ MLLRR 671_ QKARQ 676_ LEQKI 681_ NNYLT 686_ VPAHK 691_ LDSPT 696_ MSRAR 701_ IGSDP 706_ LAYEP 711_ KEDLP 716_ VITID 721_ PASPQ 726_ SPESV 731_ DLVNE 736_ ELKGK 741_ VLGLS 746_ RDPAK 751_ VAEED 756_ EDDDG 761_ GIMMR 766_ SKETS 771_ SPGTD 776_ DVFTP 781_ APSDS 786_ PSSQR 791_ IQRCL 796_ SDPGP 801_ HPEPG 806_EGEPF
1: Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511)