Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
1_MDTKH 6_ FLPLD 11_ FSTQV 16_ NSSLT 21_ SPTGR 26_ GSMAA 31_ PSLHP 36_ SLGPG 41_ IGSPG 46_ QLHSP 51_ ISTLS 56_ SPING 61_ MGPPF 66_ SVISS 71_ PMGPH 76_ SMSVP 81_ TTPTL 86_ GFSTG 91_ SPQLS 96_ SPMNP 101_ VSSSE 106_ DIKPP 111_ LGLNG 116_ VLKVP 121_ AHPSG 126_ NMASF 131_ TKHIC 136_ AICGD 141_ RSSGK 146_ HYGVY 151_ SCEGC 156_ KGFFK 161_ RTVRK 166_ DLTYT 171_ CRDNK 176_ DCLID 181_ KRQRN 186_ RCQYC 191_ RYQKC 196_ LAMGM 201_ KREAV 206_ QEERQ 211_ RGKDR 216_ NENEV 221_ ESTSS 226_ ANEDM 231_ PVERI 236_ LEAEL 241_ AVEPK 246_ TETYV 251_ EANMG 256_ LNPSS 261_ PNDPV 266_ TNICQ 271_ AADKQ 276_ LFTLV 281_ EWAKR 286_ IPHFS 291_ ELPLD 296_ DQVIL 301_ LRAGW 306_ NELLI 311_ ASFSH 316_ RSIAV 321_ KDGIL 326_ LATGL 331_ HVHRN 336_ SAHSA 341_ GVGAI 346_ FDRVL 351_ TELVS 356_ KMRDM 361_ QMDKT 366_ ELGCL 371_ RAIVL 376_ FNPDS 381_ KGLSN 386_ PAEVE 391_ ALREK 396_ VYASL 401_ EAYCK 406_ HKYPE 411_ QPGRF 416_ AKLLL 421_ RLPAL 426_ RSIGL 431_ KCLEH 436_ LFFFK 441_ LIGDT 446_ PIDTF 451_ LMEML 456_EAPHQ
1: Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632)