Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)
1_MSLVE 6_ AISLW 11_ NEGVL 16_ AADKK 21_ DWKGA 26_ LDAFS 31_ AVQDP 36_ HSRIC 41_ FNIGC 46_ MYTIL 51_ KNMTE 56_ AEKAF 61_ TRSIN 66_ RDKHL 71_ AVAYF 76_ QRGML 81_ YYQTE 86_ KYDLA 91_ IKDLK 96_ EALIQ 101_ LRGNQ 106_ LIDYK 111_ ILGLQ 116_ FKLFA 121_ CEVLY 126_ NIAFM 131_ YAKKE 136_ EWKKA 141_ EEQLA 146_ LATSM 151_ KSEPR 156_ HSKID 161_ KAMEC 166_ VWKQK 171_ LYEPV 176_ VIPVG 181_ KLFRP 186_ NERQV 191_ AQLAK 196_ KDYLG 201_ KATVV 206_ ASVVD 211_ QDSFS 216_ GFAPL 221_ QPQAA 226_ EPPPR 231_ PKTPE 236_ IFRAL 241_ EGEAH 246_ RVLFG 251_ FVPET 256_ KEELQ 261_ VMPGN 266_ IVFVL 271_ KKGND 276_ NWATV 281_ MFNGQ 286_ KGLVP 291_ CNYLE 296_ PVELR 301_ IHPQQ 306_ QPQEE 311_ SSPQS 316_ DIPAP 321_ PSSKA 326_ PGRPQ 331_ LSPGQ 336_ KQKEE 341_ PKEVK 346_ LSVPM 351_ PYTLK 356_ VHYKY 361_ TVVMK 366_ TQPGL 371_ PYSQV 376_ RDMVS 381_ KKLEL 386_ RLEHT 391_ KLSYR 396_ PRDSN 401_ ELVPL 406_ SEDSM 411_ KDAWG 416_ QVKNY 421_ CLTLW 426_ CENTV 431_ GDQGF 436_ PDEPK 441_ ESEKA 446_ DANNQ 451_ TTEPQ 456_ LKKGS 461_ QVEAL 466_ FSYEA 471_ TQPED 476_ LEFQE 481_ GDIIL 486_ VLSKV 491_ NEEWL 496_ EGECK 501_ GKVGI 506_ FPKVF 511_ VEDCA 516_ TTDLE 521_STRRE
1: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)