Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)
1_MAALM 6_ TPGTG 11_ APPAP 16_ GDFSG 21_ EGSQG 26_ LPDPS 31_ PEPKQ 36_ LPELI 41_ RMKRD 46_ GGRLS 51_ EADIR 56_ GFVAA 61_ VVNGS 66_ AQGAQ 71_ IGAML 76_ MAIRL 81_ RGMDL 86_ EETSV 91_ LTQAL 96_ AQSGQ 101_ QLEWP 106_ EAWRQ 111_ QLVDK 116_ HSTGG 121_ VGDKV 126_ SLVLA 131_ PALAA 136_ CGCKV 141_ PMISG 146_ RGLGH 151_ TGGTL 156_ DKLES 161_ IPGFN 166_ VIQSP 171_ EQMQV 176_ LLDQA 181_ GCCIV 186_ GQSEQ 191_ LVPAD 196_ GILYA 201_ ARDVT 206_ ATVDS 211_ LPLIT 216_ ASILS 221_ KKLVE 226_ GLSAL 231_ VVDVK 236_ FGGAA 241_ VFPNQ 246_ EQARE 251_ LAKTL 256_ VGVGA 261_ SLGLR 266_ VAAAL 271_ TAMDK 276_ PLGRC 281_ VGHAL 286_ EVEEA 291_ LLCMD 296_ GAGPP 301_ DLRDL 306_ VTTLG 311_ GALLW 316_ LSGHA 321_ GTQAQ 326_ GAARV 331_ AAALD 336_ DGSAL 341_ GRFER 346_ MLAAQ 351_ GVDPG 356_ LARAL 361_ CSGSP 366_ AERRQ 371_ LLPRA 376_ REQEE 381_ LLAPA 386_ DGTVE 391_ LVRAL 396_ PLALV 401_ LHELG 406_ AGRSR 411_ AGEPL 416_ RLGVG 421_ AELLV 426_ DVGQR 431_ LRRGT 436_ PWLRV 441_ HRDGP 446_ ALSGP 451_ QSRAL 456_ QEALV 461_ LSDRA 466_ PFAAP 471_ SPFAE 476_LVLPP
1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro
2: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis