Gene name: EIF2S2

Uniprot entry:

P20042

Protein names:

Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)

Protein sequence:

1_MSGDE 6_ MIFDP 11_ TMSKK 16_ KKKKK 21_ KPFML 26_ DEEGD 31_ TQTEE 36_ TQPSE 41_ TKEVE 46_ PEPTE 51_ DKDLE 56_ ADEED 61_ TRKKD 66_ ASDDL 71_ DDLNF 76_ FNQKK 81_ KKKKT 86_ KKIFD 91_ IDEAE 96_ EGVKD 101_ LKIES 106_ DVQEP 111_ TEPED 116_ DLDIM 121_ LGNKK 126_ KKKKN 131_ VKFPD 136_ EDEIL 141_ EKDEA 146_ LEDED 151_ NKKDD 156_ GISFS 161_ NQTGP 166_ AWAGS 171_ ERDYT 176_ YEELL 181_ NRVFN 186_ IMREK 191_ NPDMV 196_ AGEKR 201_ KFVMK 206_ PPQVV 211_ RVGTK 216_ KTSFV 221_ NFTDI 226_ CKLLH 231_ RQPKH 236_ LLAFL 241_ LAELG 246_ TSGSI 251_ DGNNQ 256_ LVIKG 261_ RFQQK 266_ QIENV 271_ LRRYI 276_ KEYVT 281_ CHTCR 286_ SPDTI 291_ LQKDT 296_ RLYFL 301_ QCETC 306_ HSRCS 311_ VASIK 316_ TGFQA 321_ VTGKR 326_AQLRA

Protein annotations

Protein functions:

1: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity)