Gene name: SPINK2

Uniprot entry:

P20155

Protein names:

Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)

Protein sequence:

1_MALSV 6_ LRLAL 11_ LLLAV 16_ TFAAS 21_ LIPQF 26_ GLFSK 31_ YRTPN 36_ CSQYR 41_ LPGCP 46_ RHFNP 51_ VCGSD 56_ MSTYA 61_ NECTL 66_ CMKIR 71_ EGGHN 76_IKIIR

Protein annotations

Protein functions:

1: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin