Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP)
1_MTRLT 6_ VLALL 11_ AGLLA 16_ SSRAG 21_ SSPLL 26_ DIVGG 31_ RKARP 36_ RQFPF 41_ LASIQ 46_ NQGRH 51_ FCGGA 56_ LIHAR 61_ FVMTA 66_ ASCFQ 71_ SQNPG 76_ VSTVV 81_ LGAYD 86_ LRRRE 91_ RQSRQ 96_ TFSIS 101_ SMSEN 106_ GYDPQ 111_ QNLND 116_ LMLLQ 121_ LDREA 126_ NLTSS 131_ VTILP 136_ LPLQN 141_ ATVEA 146_ GTRCQ 151_ VAGWG 156_ SQRSG 161_ GRLSR 166_ FPRFV 171_ NVTVT 176_ PEDQC 181_ RPNNV 186_ CTGVL 191_ TRRGG 196_ ICNGD 201_ GGTPL 206_ VCEGL 211_ AHGVA 216_ SFSLG 221_ PCGRG 226_ PDFFT 231_ RVALF 236_ RDWID 241_ GVLNN 246_PGPGP
1: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G