TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
1_MDQNN 6_ SLPPY 11_ AQGLA 16_ SPQGA 21_ MTPGI 26_ PIFSP 31_ MMPYG 36_ TGLTP 41_ QPIQN 46_ TNSLS 51_ ILEEQ 56_ QRQQQ 61_ QQQQQ 66_ QQQQQ 71_ QQQQQ 76_ QQQQQ 81_ QQQQQ 86_ QQQQQ 91_ QQQQQ 96_ AVAAA 101_ AVQQS 106_ TSQQA 111_ TQGTS 116_ GQAPQ 121_ LFHSQ 126_ TLTTA 131_ PLPGT 136_ TPLYP 141_ SPMTP 146_ MTPIT 151_ PATPA 156_ SESSG 161_ IVPQL 166_ QNIVS 171_ TVNLG 176_ CKLDL 181_ KTIAL 186_ RARNA 191_ EYNPK 196_ RFAAV 201_ IMRIR 206_ EPRTT 211_ ALIFS 216_ SGKMV 221_ CTGAK 226_ SEEQS 231_ RLAAR 236_ KYARV 241_ VQKLG 246_ FPAKF 251_ LDFKI 256_ QNMVG 261_ SCDVK 266_ FPIRL 271_ EGLVL 276_ THQQF 281_ SSYEP 286_ ELFPG 291_ LIYRM 296_ IKPRI 301_ VLLIF 306_ VSGKV 311_ VLTGA 316_ KVRAE 321_ IYEAF 326_ ENIYP 331_ILKGF
1: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:2194289, PubMed:2363050, PubMed:2374612, PubMed:27193682, PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846, PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TBP forms the TFIID-A module together with TAF3 and TAF5 (PubMed:33795473). TBP is a general transcription factor that functions at the core of the TFIID complex (PubMed:2194289, PubMed:2363050, PubMed:2374612, PubMed:27193682, PubMed:33795473, PubMed:9836642). During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box (PubMed:33795473). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter (PubMed:15970593). SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (PubMed:15970593)