POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7)
1_MATAA 6_ SNHYS 11_ LLTSS 16_ ASIVH 21_ AEPPG 26_ GMQQG 31_ AGGYR 36_ EAQSL 41_ VQGDY 46_ GALQS 51_ NGHPL 56_ SHAHQ 61_ WITAL 66_ SHGGG 71_ GGGGG 76_ GGGGG 81_ GGGGG 86_ GGGDG 91_ SPWST 96_ SPLGQ 101_ PDIKP 106_ SVVVQ 111_ QGGRG 116_ DELHG 121_ PGALQ 126_ QQHQQ 131_ QQQQQ 136_ QQQQQ 141_ QQQQQ 146_ QQQQR 151_ PPHLV 156_ HHAAN 161_ HHPGP 166_ GAWRS 171_ AAAAA 176_ HLPPS 181_ MGASN 186_ GGLLY 191_ SQPSF 196_ TVNGM 201_ LGAGG 206_ QPAGL 211_ HHHGL 216_ RDAHD 221_ EPHHA 226_ DHHPH 231_ PHSHP 236_ HQQPP 241_ PPPPP 246_ QGPPG 251_ HPGAH 256_ HDPHS 261_ DEDTP 266_ TSDDL 271_ EQFAK 276_ QFKQR 281_ RIKLG 286_ FTQAD 291_ VGLAL 296_ GTLYG 301_ NVFSQ 306_ TTICR 311_ FEALQ 316_ LSFKN 321_ MCKLK 326_ PLLNK 331_ WLEEA 336_ DSSSG 341_ SPTSI 346_ DKIAA 351_ QGRKR 356_ KKRTS 361_ IEVSV 366_ KGALE 371_ SHFLK 376_ CPKPS 381_ AQEIT 386_ SLADS 391_ LQLEK 396_ EVVRV 401_ WFCNR 406_ RQKEK 411_ RMTPP 416_ GGTLP 421_ GAEDV 426_ YGGSR 431_ DTPPH 436_HGVQT
1: Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity)