Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)
1_MRRTG 6_ APAQA 11_ DSRGR 16_ GRARG 21_ GCPGG 26_ EATLS 31_ QPPPR 36_ GGTRG 41_ QEPQM 46_ KETIM 51_ NQEKL 56_ AKLQA 61_ QVRIG 66_ GKGTA 71_ RRKKK 76_ VVHRT 81_ ATADD 86_ KKLQF 91_ SLKKL 96_ GVNNI 101_ SGIEE 106_ VNMFT 111_ NQGTV 116_ IHFNN 121_ PKVQA 126_ SLAAN 131_ TFTIT 136_ GHAET 141_ KQLTE 146_ MLPSI 151_ LNQLG 156_ ADSLT 161_ SLRRL 166_ AEALP 171_ KQSVD 176_ GKAPL 181_ ATGED 186_ DDDEV 191_ PDLVE 196_ NFDEA 201_SKNEA
1: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription