Gene name: ALOX5AP

Uniprot entry:

P20292

Protein names:

Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein)

Protein sequence:

1_MDQET 6_ VGNVV 11_ LLAIV 16_ TLISV 21_ VQNGF 26_ FAHKV 31_ EHESR 36_ TQNGR 41_ SFQRT 46_ GTLAF 51_ ERVYT 56_ ANQNC 61_ VDAYP 66_ TFLAV 71_ LWSAG 76_ LLCSQ 81_ VPAAF 86_ AGLMY 91_ LFVRQ 96_ KYFVG 101_ YLGER 106_ TQSTP 111_ GYIFG 116_ KRIIL 121_ FLFLM 126_ SVAGI 131_ FNYYL 136_ IFFFG 141_ SDFEN 146_ YIKTI 151_ STTIS 156_PLLLI

Protein annotations

Protein functions:

1: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes