Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
1_MAPVA 6_ VWAAL 11_ AVGLE 16_ LWAAA 21_ HALPA 26_ QVAFT 31_ PYAPE 36_ PGSTC 41_ RLREY 46_ YDQTA 51_ QMCCS 56_ KCSPG 61_ QHAKV 66_ FCTKT 71_ SDTVC 76_ DSCED 81_ STYTQ 86_ LWNWV 91_ PECLS 96_ CGSRC 101_ SSDQV 106_ ETQAC 111_ TREQN 116_ RICTC 121_ RPGWY 126_ CALSK 131_ QEGCR 136_ LCAPL 141_ RKCRP 146_ GFGVA 151_ RPGTE 156_ TSDVV 161_ CKPCA 166_ PGTFS 171_ NTTSS 176_ TDICR 181_ PHQIC 186_ NVVAI 191_ PGNAS 196_ MDAVC 201_ TSTSP 206_ TRSMA 211_ PGAVH 216_ LPQPV 221_ STRSQ 226_ HTQPT 231_ PEPST 236_ APSTS 241_ FLLPM 246_ GPSPP 251_ AEGST 256_ GDFAL 261_ PVGLI 266_ VGVTA 271_ LGLLI 276_ IGVVN 281_ CVIMT 286_ QVKKK 291_ PLCLQ 296_ REAKV 301_ PHLPA 306_ DKARG 311_ TQGPE 316_ QQHLL 321_ ITAPS 326_ SSSSS 331_ LESSA 336_ SALDR 341_ RAPTR 346_ NQPQA 351_ PGVEA 356_ SGAGE 361_ ARAST 366_ GSSDS 371_ SPGGH 376_ GTQVN 381_ VTCIV 386_ NVCSS 391_ SDHSS 396_ QCSSQ 401_ ASSTM 406_ GDTDS 411_ SPSES 416_ PKDEQ 421_ VPFSK 426_ EECAF 431_ RSQLE 436_ TPETL 441_ LGSTE 446_ EKPLP 451_ LGVPD 456_AGMKP
1: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity