Gene name: RAB4A

Uniprot entry:

P20338

Protein names:

Ras-related protein Rab-4A (EC 3.6.5.2)

Protein sequence:

1_MSQTA 6_ MSETY 11_ DFLFK 16_ FLVIG 21_ NAGTG 26_ KSCLL 31_ HQFIE 36_ KKFKD 41_ DSNHT 46_ IGVEF 51_ GSKII 56_ NVGGK 61_ YVKLQ 66_ IWDTA 71_ GQERF 76_ RSVTR 81_ SYYRG 86_ AAGAL 91_ LVYDI 96_ TSRET 101_ YNALT 106_ NWLTD 111_ ARMLA 116_ SQNIV 121_ IILCG 126_ NKKDL 131_ DADRE 136_ VTFLE 141_ ASRFA 146_ QENEL 151_ MFLET 156_ SALTG 161_ ENVEE 166_ AFVQC 171_ ARKIL 176_ NKIES 181_ GELDP 186_ ERMGS 191_ GIQYG 196_ DAALR 201_ QLRSP 206_ RRAQA 211_PNAQE

Protein annotations

Protein functions:

1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)