Gene name: RAB5A

Uniprot entry:

P20339

Protein names:

Ras-related protein Rab-5A (EC 3.6.5.2)

Protein sequence:

1_MASRG 6_ ATRPN 11_ GPNTG 16_ NKICQ 21_ FKLVL 26_ LGESA 31_ VGKSS 36_ LVLRF 41_ VKGQF 46_ HEFQE 51_ STIGA 56_ AFLTQ 61_ TVCLD 66_ DTTVK 71_ FEIWD 76_ TAGQE 81_ RYHSL 86_ APMYY 91_ RGAQA 96_ AIVVY 101_ DITNE 106_ ESFAR 111_ AKNWV 116_ KELQR 121_ QASPN 126_ IVIAL 131_ SGNKA 136_ DLANK 141_ RAVDF 146_ QEAQS 151_ YADDN 156_ SLLFM 161_ ETSAK 166_ TSMNV 171_ NEIFM 176_ AIAKK 181_ LPKNE 186_ PQNPG 191_ ANSAR 196_ GRGVD 201_ LTEPT 206_QPTRN

Protein annotations

Protein functions:

1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity)