Ras-related protein Rab-6A (Rab-6)
1_MSTGG 6_ DFGNP 11_ LRKFK 16_ LVFLG 21_ EQSVG 26_ KTSLI 31_ TRFMY 36_ DSFDN 41_ TYQAT 46_ IGIDF 51_ LSKTM 56_ YLEDR 61_ TVRLQ 66_ LWDTA 71_ GQERF 76_ RSLIP 81_ SYIRD 86_ STVAV 91_ VVYDI 96_ TNVNS 101_ FQQTT 106_ KWIDD 111_ VRTER 116_ GSDVI 121_ IMLVG 126_ NKTDL 131_ ADKRQ 136_ VSIEE 141_ GERKA 146_ KELNV 151_ MFIET 156_ SAKAG 161_ YNVKQ 166_ LFRRV 171_ AAALP 176_ GMEST 181_ QDRSR 186_ EDMID 191_ IKLEK 196_ PQEQP 201_VSEGG
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable)