Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)
1_MLSST 6_ AMYSA 11_ PGRDL 16_ GMEPH 21_ RAAGP 26_ LQLRF 31_ SPYVF 36_ NGGTI 41_ LAIAG 46_ EDFAI 51_ VASDT 56_ RLSEG 61_ FSIHT 66_ RDSPK 71_ CYKLT 76_ DKTVI 81_ GCSGF 86_ HGDCL 91_ TLTKI 96_ IEARL 101_ KMYKH 106_ SNNKA 111_ MTTGA 116_ IAAML 121_ STILY 126_ SRRFF 131_ PYYVY 136_ NIIGG 141_ LDEEG 146_ KGAVY 151_ SFDPV 156_ GSYQR 161_ DSFKA 166_ GGSAS 171_ AMLQP 176_ LLDNQ 181_ VGFKN 186_ MQNVE 191_ HVPLS 196_ LDRAM 201_ RLVKD 206_ VFISA 211_ AERDV 216_ YTGDA 221_ LRICI 226_ VTKEG 231_ IREET 236_VSLRK
1: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)