Gene name: M6PR

Uniprot entry:

P20645

Protein names:

Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)

Protein sequence:

1_MFPFY 6_ SCWRT 11_ GLLLL 16_ LLAVA 21_ VRESW 26_ QTEEK 31_ TCDLV 36_ GEKGK 41_ ESEKE 46_ LALVK 51_ RLKPL 56_ FNKSF 61_ ESTVG 66_ QGSDT 71_ YIYIF 76_ RVCRE 81_ AGNHT 86_ SGAGL 91_ VQINK 96_ SNGKE 101_ TVVGR 106_ LNETH 111_ IFNGS 116_ NWIML 121_ IYKGG 126_ DEYDN 131_ HCGKE 136_ QRRAV 141_ VMISC 146_ NRHTL 151_ ADNFN 156_ PVSEE 161_ RGKVQ 166_ DCFYL 171_ FEMDS 176_ SLACS 181_ PEISH 186_ LSVGS 191_ ILLVT 196_ FASLV 201_ AVYVV 206_ GGFLY 211_ QRLVV 216_ GAKGM 221_ EQFPH 226_ LAFWQ 231_ DLGNL 236_ VADGC 241_ DFVCR 246_ SKPRN 251_ VPAAY 256_ RGVGD 261_ DQLGE 266_ ESEER 271_DDHLL

Protein annotations

Protein functions:

1: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex