Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
1_MGKAE 6_ NYELY 11_ SVELG 16_ PGPGG 21_ DMAAK 26_ MSKKK 31_ KAGGG 36_ GGKRK 41_ EKLEN 46_ MKKEM 51_ EINDH 56_ QLSVA 61_ ELEQK 66_ YQTSA 71_ TKGLS 76_ ASLAA 81_ ELLLR 86_ DGPNA 91_ LRPPR 96_ GTPEY 101_ VKFAR 106_ QLAGG 111_ LQCLM 116_ WVAAA 121_ ICLIA 126_ FAIQA 131_ SEGDL 136_ TTDDN 141_ LYLAI 146_ ALIAV 151_ VVVTG 156_ CFGYY 161_ QEFKS 166_ TNIIA 171_ SFKNL 176_ VPQQA 181_ TVIRD 186_ GDKFQ 191_ INADQ 196_ LVVGD 201_ LVEMK 206_ GGDRV 211_ PADIR 216_ ILAAQ 221_ GCKVD 226_ NSSLT 231_ GESEP 236_ QTRSP 241_ ECTHE 246_ SPLET 251_ RNIAF 256_ FSTMC 261_ LEGTV 266_ QGLVV 271_ NTGDR 276_ TIIGR 281_ IASLA 286_ SGVEN 291_ EKTPI 296_ AIEIE 301_ HFVDI 306_ IAGLA 311_ ILFGA 316_ TFFIV 321_ AMCIG 326_ YTFLR 331_ AMVFF 336_ MAIVV 341_ AYVPE 346_ GLLAT 351_ VTVCL 356_ SLTAK 361_ RLASK 366_ NCVVK 371_ NLEAV 376_ ETLGS 381_ TSVIC 386_ SDKTG 391_ TLTQN 396_ RMTVS 401_ HLWFD 406_ NHIHT 411_ ADTTE 416_ DQSGQ 421_ TFDQS 426_ SETWR 431_ ALCRV 436_ LTLCN 441_ RAAFK 446_ SGQDA 451_ VPVPK 456_ RIVIG 461_ DASET 466_ ALLKF 471_ SELTL 476_ GNAMG 481_ YRDRF 486_ PKVCE 491_ IPFNS 496_ TNKFQ 501_ LSIHT 506_ LEDPR 511_ DPRHL 516_ LVMKG 521_ APERV 526_ LERCS 531_ SILIK 536_ GQELP 541_ LDEQW 546_ REAFQ 551_ TAYLS 556_ LGGLG 561_ ERVLG 566_ FCQLY 571_ LNEKD 576_ YPPGY 581_ AFDVE 586_ AMNFP 591_ SSGLC 596_ FAGLV 601_ SMIDP 606_ PRATV 611_ PDAVL 616_ KCRTA 621_ GIRVI 626_ MVTGD 631_ HPITA 636_ KAIAA 641_ SVGII 646_ SEGSE 651_ TVEDI 656_ AARLR 661_ VPVDQ 666_ VNRKD 671_ ARACV 676_ INGMQ 681_ LKDMD 686_ PSELV 691_ EALRT 696_ HPEMV 701_ FARTS 706_ PQQKL 711_ VIVES 716_ CQRLG 721_ AIVAV 726_ TGDGV 731_ NDSPA 736_ LKKAD 741_ IGVAM 746_ GIAGS 751_ DAAKN 756_ AADMI 761_ LLDDN 766_ FASIV 771_ TGVEQ 776_ GRLIF 781_ DNLKK 786_ SIAYT 791_ LTKNI 796_ PELTP 801_ YLIYI 806_ TVSVP 811_ LPLGC 816_ ITILF 821_ IELCT 826_ DIFPS 831_ VSLAY 836_ EKAES 841_ DIMHL 846_ RPRNP 851_ KRDRL 856_ VNEPL 861_ AAYSY 866_ FQIGA 871_ IQSFA 876_ GFTDY 881_ FTAMA 886_ QEGWF 891_ PLLCV 896_ GLRAQ 901_ WEDHH 906_ LQDLQ 911_ DSYGQ 916_ EWTFG 921_ QRLYQ 926_ QYTCY 931_ TVFFI 936_ SIEVC 941_ QIADV 946_ LIRKT 951_ RRLSA 956_ FQQGF 961_ FRNKI 966_ LVIAI 971_ VFQVC 976_ IGCFL 981_ CYCPG 986_ MPNIF 991_ NFMPI 996_ RFQWW 1001_ LVPLP 1006_ YGILI 1011_ FVYDE 1016_ IRKLG 1021_ VRCCP 1026_GSWWD
1: The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity)