Lamin-B1
1_MATAT 6_ PVPPR 11_ MGSRA 16_ GGPTT 21_ PLSPT 26_ RLSRL 31_ QEKEE 36_ LRELN 41_ DRLAV 46_ YIDKV 51_ RSLET 56_ ENSAL 61_ QLQVT 66_ EREEV 71_ RGREL 76_ TGLKA 81_ LYETE 86_ LADAR 91_ RALDD 96_ TARER 101_ AKLQI 106_ ELGKC 111_ KAEHD 116_ QLLLN 121_ YAKKE 126_ SDLNG 131_ AQIKL 136_ REYEA 141_ ALNSK 146_ DAALA 151_ TALGD 156_ KKSLE 161_ GDLED 166_ LKDQI 171_ AQLEA 176_ SLAAA 181_ KKQLA 186_ DETLL 191_ KVDLE 196_ NRCQS 201_ LTEDL 206_ EFRKS 211_ MYEEE 216_ INETR 221_ RKHET 226_ RLVEV 231_ DSGRQ 236_ IEYEY 241_ KLAQA 246_ LHEMR 251_ EQHDA 256_ QVRLY 261_ KEELE 266_ QTYHA 271_ KLENA 276_ RLSSE 281_ MNTST 286_ VNSAR 291_ EELME 296_ SRMRI 301_ ESLSS 306_ QLSNL 311_ QKESR 316_ ACLER 321_ IQELE 326_ DLLAK 331_ EKDNS 336_ RRMLT 341_ DKERE 346_ MAEIR 351_ DQMQQ 356_ QLNDY 361_ EQLLD 366_ VKLAL 371_ DMEIS 376_ AYRKL 381_ LEGEE 386_ ERLKL 391_ SPSPS 396_ SRVTV 401_ SRASS 406_ SRSVR 411_ TTRGK 416_ RKRVD 421_ VEESE 426_ ASSSV 431_ SISHS 436_ ASATG 441_ NVCIE 446_ EIDVD 451_ GKFIR 456_ LKNTS 461_ EQDQP 466_ MGGWE 471_ MIRKI 476_ GDTSV 481_ SYKYT 486_ SRYVL 491_ KAGQT 496_ VTIWA 501_ ANAGV 506_ TASPP 511_ TDLIW 516_ KNQNS 521_ WGTGE 526_ DVKVI 531_ LKNSQ 536_ GEEVA 541_ QRSTV 546_ FKTTI 551_ PEEEE 556_ EEEEA 561_ AGVVV 566_ EEELF 571_ HQQGT 576_ PRASN 581_RSCAI
1: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914)