Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
1_MKDSC 6_ ITVMA 11_ MALLS 16_ GFFFF 21_ APASS 26_ YNLDV 31_ RGARS 36_ FSPPR 41_ AGRHF 46_ GYRVL 51_ QVGNG 56_ VIVGA 61_ PGEGN 66_ STGSL 71_ YQCQS 76_ GTGHC 81_ LPVTL 86_ RGSNY 91_ TSKYL 96_ GMTLA 101_ TDPTD 106_ GSILA 111_ CDPGL 116_ SRTCD 121_ QNTYL 126_ SGLCY 131_ LFRQN 136_ LQGPM 141_ LQGRP 146_ GFQEC 151_ IKGNV 156_ DLVFL 161_ FDGSM 166_ SLQPD 171_ EFQKI 176_ LDFMK 181_ DVMKK 186_ LSNTS 191_ YQFAA 196_ VQFST 201_ SYKTE 206_ FDFSD 211_ YVKRK 216_ DPDAL 221_ LKHVK 226_ HMLLL 231_ TNTFG 236_ AINYV 241_ ATEVF 246_ REELG 251_ ARPDA 256_ TKVLI 261_ IITDG 266_ EATDS 271_ GNIDA 276_ AKDII 281_ RYIIG 286_ IGKHF 291_ QTKES 296_ QETLH 301_ KFASK 306_ PASEF 311_ VKILD 316_ TFEKL 321_ KDLFT 326_ ELQKK 331_ IYVIE 336_ GTSKQ 341_ DLTSF 346_ NMELS 351_ SSGIS 356_ ADLSR 361_ GHAVV 366_ GAVGA 371_ KDWAG 376_ GFLDL 381_ KADLQ 386_ DDTFI 391_ GNEPL 396_ TPEVR 401_ AGYLG 406_ YTVTW 411_ LPSRQ 416_ KTSLL 421_ ASGAP 426_ RYQHM 431_ GRVLL 436_ FQEPQ 441_ GGGHW 446_ SQVQT 451_ IHGTQ 456_ IGSYF 461_ GGELC 466_ GVDVD 471_ QDGET 476_ ELLLI 481_ GAPLF 486_ YGEQR 491_ GGRVF 496_ IYQRR 501_ QLGFE 506_ EVSEL 511_ QGDPG 516_ YPLGR 521_ FGEAI 526_ TALTD 531_ INGDG 536_ LVDVA 541_ VGAPL 546_ EEQGA 551_ VYIFN 556_ GRHGG 561_ LSPQP 566_ SQRIE 571_ GTQVL 576_ SGIQW 581_ FGRSI 586_ HGVKD 591_ LEGDG 596_ LADVA 601_ VGAES 606_ QMIVL 611_ SSRPV 616_ VDMVT 621_ LMSFS 626_ PAEIP 631_ VHEVE 636_ CSYST 641_ SNKMK 646_ EGVNI 651_ TICFQ 656_ IKSLI 661_ PQFQG 666_ RLVAN 671_ LTYTL 676_ QLDGH 681_ RTRRR 686_ GLFPG 691_ GRHEL 696_ RRNIA 701_ VTTSM 706_ SCTDF 711_ SFHFP 716_ VCVQD 721_ LISPI 726_ NVSLN 731_ FSLWE 736_ EEGTP 741_ RDQRA 746_ QGKDI 751_ PPILR 756_ PSLHS 761_ ETWEI 766_ PFEKN 771_ CGEDK 776_ KCEAN 781_ LRVSF 786_ SPARS 791_ RALRL 796_ TAFAS 801_ LSVEL 806_ SLSNL 811_ EEDAY 816_ WVQLD 821_ LHFPP 826_ GLSFR 831_ KVEML 836_ KPHSQ 841_ IPVSC 846_ EELPE 851_ ESRLL 856_ SRALS 861_ CNVSS 866_ PIFKA 871_ GHSVA 876_ LQMMF 881_ NTLVN 886_ SSWGD 891_ SVELH 896_ ANVTC 901_ NNEDS 906_ DLLED 911_ NSATT 916_ IIPIL 921_ YPINI 926_ LIQDQ 931_ EDSTL 936_ YVSFT 941_ PKGPK 946_ IHQVK 951_ HMYQV 956_ RIQPS 961_ IHDHN 966_ IPTLE 971_ AVVGV 976_ PQPPS 981_ EGPIT 986_ HQWSV 991_ QMEPP 996_ VPCHY 1001_ EDLER 1006_ LPDAA 1011_ EPCLP 1016_ GALFR 1021_ CPVVF 1026_ RQEIL 1031_ VQVIG 1036_ TLELV 1041_ GEIEA 1046_ SSMFS 1051_ LCSSL 1056_ SISFN 1061_ SSKHF 1066_ HLYGS 1071_ NASLA 1076_ QVVMK 1081_ VDVVY 1086_ EKQML 1091_ YLYVL 1096_ SGIGG 1101_ LLLLL 1106_ LIFIV 1111_ LYKVG 1116_ FFKRN 1121_ LKEKM 1126_ EAGRG 1131_ VPNGI 1136_ PAEDS 1141_ EQLAS 1146_ GQEAG 1151_ DPGCL 1156_ KPLHE 1161_KDSES
1: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590)