Gene name: GZMH

Uniprot entry:

P20718

Protein names:

Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C)

Protein sequence:

1_MQPFL 6_ LLLAF 11_ LLTPG 16_ AGTEE 21_ IIGGH 26_ EAKPH 31_ SRPYM 36_ AFVQF 41_ LQEKS 46_ RKRCG 51_ GILVR 56_ KDFVL 61_ TAAHC 66_ QGSSI 71_ NVTLG 76_ AHNIK 81_ EQERT 86_ QQFIP 91_ VKRPI 96_ PHPAY 101_ NPKNF 106_ SNDIM 111_ LLQLE 116_ RKAKW 121_ TTAVR 126_ PLRLP 131_ SSKAQ 136_ VKPGQ 141_ LCSVA 146_ GWGYV 151_ SMSTL 156_ ATTLQ 161_ EVLLT 166_ VQKDC 171_ QCERL 176_ FHGNY 181_ SRATE 186_ ICVGD 191_ PKKTQ 196_ TGFKG 201_ DSGGP 206_ LVCKD 211_ VAQGI 216_ LSYGN 221_ KKGTP 226_ PGVYI 231_ KVSHF 236_ LPWIK 241_RTMKR

Protein annotations

Protein functions:

1: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication