Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)
1_MRKDR 6_ LLHLC 11_ LVLLL 16_ ILLSA 21_ SDSNS 26_ TEPQY 31_ MVLVP 36_ SLLHT 41_ EAPKK 46_ GCVLL 51_ SHLNE 56_ TVTVS 61_ ASLES 66_ GRENR 71_ SLFTD 76_ LVAEK 81_ DLFHC 86_ VSFTL 91_ PRISA 96_ SSEVA 101_ FLSIQ 106_ IKGPT 111_ QDFRK 116_ RNTVL 121_ VLNTQ 126_ SLVFV 131_ QTDKP 136_ MYKPG 141_ QTVRF 146_ RVVSV 151_ DENFR 156_ PRNEL 161_ IPLIY 166_ LENPR 171_ RNRIA 176_ QWQSL 181_ KLEAG 186_ INQLS 191_ FPLSS 196_ EPIQG 201_ SYRVV 206_ VQTES 211_ GGRIQ 216_ HPFTV 221_ EEFVL 226_ PKFEV 231_ KVQVP 236_ KIISI 241_ MDEKV 246_ NITVC 251_ GEYTY 256_ GKPVP 261_ GLATV 266_ SLCRK 271_ LSRVL 276_ NCDKQ 281_ EVCEE 286_ FSQQL 291_ NSNGC 296_ ITQQV 301_ HTKML 306_ QITNT 311_ GFEMK 316_ LRVEA 321_ RIREE 326_ GTDLE 331_ VTANR 336_ ISEIT 341_ NIVSK 346_ LKFVK 351_ VDSHF 356_ RQGIP 361_ FFAQV 366_ LLVDG 371_ KGVPI 376_ PNKLF 381_ FISVN 386_ DANYY 391_ SNATT 396_ NEQGL 401_ AQFSI 406_ NTTSI 411_ SVNKL 416_ FVRVF 421_ TVHPN 426_ LCFHY 431_ SWVAE 436_ DHQGA 441_ QHTAN 446_ RVFSL 451_ SGSYI 456_ HLEPV 461_ AGTLP 466_ CGHTE 471_ TITAH 476_ YTLNR 481_ QAMGE 486_ LSELS 491_ FHYLI 496_ MAKGV 501_ IVRSG 506_ THTLP 511_ VESGD 516_ MKGSF 521_ ALSFP 526_ VESDV 531_ APIAR 536_ MFIFA 541_ ILPDG 546_ EVVGD 551_ SEKFE 556_ IENCL 561_ ANKVD 566_ LSFSP 571_ AQSPP 576_ ASHAH 581_ LQVAA 586_ APQSL 591_ CALRA 596_ VDQSV 601_ LLMKP 606_ EAELS 611_ VSSVY 616_ NLLTV 621_ KDLTN 626_ FPDNV 631_ DQQEE 636_ EQGHC 641_ PRPFF 646_ IHNGA 651_ IYVPL 656_ SSNEA 661_ DIYSF 666_ LKGMG 671_ LKVFT 676_ NSKIR 681_ KPKSC 686_ SVIPS 691_ VSAGA 696_ VGQGY 701_ YGAGL 706_ GVVER 711_ PYVPQ 716_ LGTYN 721_ VIPLN 726_ NEQSS 731_ GPVPE 736_ TVRSY 741_ FPETW 746_ IWELV 751_ AVNSS 756_ GVAEV 761_ GVTVP 766_ DTITE 771_ WKAGA 776_ FCLSE 781_ DAGLG 786_ ISSTA 791_ SLRAF 796_ QPFFV 801_ ELTMP 806_ YSVIR 811_ GEVFT 816_ LKATV 821_ LNYLP 826_ KCIRV 831_ SVQLK 836_ ASPAF 841_ LASQN 846_ TKGEE 851_ SYCIC 856_ GNERQ 861_ TLSWT 866_ VTPKT 871_ LGNVN 876_ FSVSA 881_ EAMQS 886_ LELCG 891_ NEVVE 896_ VPEIK 901_ RKDTV 906_ IKTLL 911_ VEAEG 916_ IEQEK 921_ TFSSM 926_ TCASG 931_ ANVSE 936_ QLSLK 941_ LPSNV 946_ VKESA 951_ RASFS 956_ VLGDI 961_ LGSAM 966_ QNIQN 971_ LLQMP 976_ YGCGE 981_ QNMVL 986_ FAPNI 991_ YVLNY 996_ LNETQ 1001_ QLTQE 1006_ IKAKA 1011_ VGYLI 1016_ TGYQR 1021_ QLNYK 1026_ HQDGS 1031_ YSTFG 1036_ ERYGR 1041_ NQGNT 1046_ WLTAF 1051_ VLKTF 1056_ AQARS 1061_ YIFID 1066_ EAHIT 1071_ QSLTW 1076_ LSQMQ 1081_ KDNGC 1086_ FRSSG 1091_ SLLNN 1096_ AIKGG 1101_ VEDEA 1106_ TLSAY 1111_ VTIAL 1116_ LEIPL 1121_ PVTNP 1126_ IVRNA 1131_ LFCLE 1136_ SAWNV 1141_ AKEGT 1146_ HGSHV 1151_ YTKAL 1156_ LAYAF 1161_ SLLGK 1166_ QNQNR 1171_ EILNS 1176_ LDKEA 1181_ VKEDN 1186_ LVHWE 1191_ RPQRP 1196_ KAPVG 1201_ HLYQT 1206_ QAPSA 1211_ EVEMT 1216_ SYVLL 1221_ AYLTA 1226_ QPAPT 1231_ SGDLT 1236_ SATNI 1241_ VKWIM 1246_ KQQNA 1251_ QGGFS 1256_ STQDT 1261_ VVALH 1266_ ALSRY 1271_ GAATF 1276_ TRTEK 1281_ TAQVT 1286_ VQDSQ 1291_ TFSTN 1296_ FQVDN 1301_ NNLLL 1306_ LQQIS 1311_ LPELP 1316_ GEYVI 1321_ TVTGE 1326_ RCVYL 1331_ QTSMK 1336_ YNILP 1341_ EKEDS 1346_ PFALK 1351_ VQTVP 1356_ QTCDG 1361_ HKAHT 1366_ SFQIS 1371_ LTISY 1376_ TGNRP 1381_ ASNMV 1386_ IVDVK 1391_ MVSGF 1396_ IPLKP 1401_ TVKML 1406_ ERSSS 1411_ VSRTE 1416_ VSNNH 1421_ VLIYV 1426_ EQVTN 1431_ QTLSF 1436_ SFMVL 1441_ QDIPV 1446_ GDLKP 1451_ AIVKV 1456_ YDYYE 1461_ TDESV 1466_ VAEYI 1471_ APCST 1476_DTEHG
1: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase