Gene name: IL11

Uniprot entry:

P20809

Protein names:

Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)

Protein sequence:

1_MNCVC 6_ RLVLV 11_ VLSLW 16_ PDTAV 21_ APGPP 26_ PGPPR 31_ VSPDP 36_ RAELD 41_ STVLL 46_ TRSLL 51_ ADTRQ 56_ LAAQL 61_ RDKFP 66_ ADGDH 71_ NLDSL 76_ PTLAM 81_ SAGAL 86_ GALQL 91_ PGVLT 96_ RLRAD 101_ LLSYL 106_ RHVQW 111_ LRRAG 116_ GSSLK 121_ TLEPE 126_ LGTLQ 131_ ARLDR 136_ LLRRL 141_ QLLMS 146_ RLALP 151_ QPPPD 156_ PPAPP 161_ LAPPS 166_ SAWGG 171_ IRAAH 176_ AILGG 181_ LHLTL 186_ DWAVR 191_GLLLL

Protein annotations

Protein functions:

1: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168)