Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)
1_MELSV 6_ LLFLA 11_ LLTGL 16_ LLLLV 21_ QRHPN 26_ THDRL 31_ PPGPR 36_ PLPLL 41_ GNLLQ 46_ MDRRG 51_ LLKSF 56_ LRFRE 61_ KYGDV 66_ FTVHL 71_ GPRPV 76_ VMLCG 81_ VEAIR 86_ EALVD 91_ KAEAF 96_ SGRGK 101_ IAMVD 106_ PFFRG 111_ YGVIF 116_ ANGNR 121_ WKVLR 126_ RFSVT 131_ TMRDF 136_ GMGKR 141_ SVEER 146_ IQEEA 151_ QCLIE 156_ ELRKS 161_ KGALM 166_ DPTFL 171_ FQSIT 176_ ANIIC 181_ SIVFG 186_ KRFHY 191_ QDQEF 196_ LKMLN 201_ LFYQT 206_ FSLIS 211_ SVFGQ 216_ LFELF 221_ SGFLK 226_ YFPGA 231_ HRQVY 236_ KNLQE 241_ INAYI 246_ GHSVE 251_ KHRET 256_ LDPSA 261_ PKDLI 266_ DTYLL 271_ HMEKE 276_ KSNAH 281_ SEFSH 286_ QNLNL 291_ NTLSL 296_ FFAGT 301_ ETTST 306_ TLRYG 311_ FLLML 316_ KYPHV 321_ AERVY 326_ REIEQ 331_ VIGPH 336_ RPPEL 341_ HDRAK 346_ MPYTE 351_ AVIYE 356_ IQRFS 361_ DLLPM 366_ GVPHI 371_ VTQHT 376_ SFRGY 381_ IIPKD 386_ TEVFL 391_ ILSTA 396_ LHDPH 401_ YFEKP 406_ DAFNP 411_ DHFLD 416_ ANGAL 421_ KKTEA 426_ FIPFS 431_ LGKRI 436_ CLGEG 441_ IARAE 446_ LFLFF 451_ TTILQ 456_ NFSMA 461_ SPVAP 466_ EDIDL 471_ TPQEC 476_ GVGKI 481_ PPTYQ 486_IRFLP
1: A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:12865317, PubMed:21289075). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850)
2: Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs