Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3)
1_MDLIP 6_ NLAVE 11_ TWLLL 16_ AVSLV 21_ LLYLY 26_ GTRTH 31_ GLFKR 36_ LGIPG 41_ PTPLP 46_ LLGNV 51_ LSYRQ 56_ GLWKF 61_ DTECY 66_ KKYGK 71_ MWGTY 76_ EGQLP 81_ VLAIT 86_ DPDVI 91_ RTVLV 96_ KECYS 101_ VFTNR 106_ RSLGP 111_ VGFMK 116_ SAISL 121_ AEDEE 126_ WKRIR 131_ SLLSP 136_ TFTSG 141_ KLKEM 146_ FPIIA 151_ QYGDV 156_ LVRNL 161_ RREAE 166_ KGKPV 171_ TLKDI 176_ FGAYS 181_ MDVIT 186_ GTSFG 191_ VNIDS 196_ LNNPQ 201_ DPFVE 206_ STKKF 211_ LKFGF 216_ LDPLF 221_ LSIIL 226_ FPFLT 231_ PVFEA 236_ LNVSL 241_ FPKDT 246_ INFLS 251_ KSVNR 256_ MKKSR 261_ LNDKQ 266_ KHRLD 271_ FLQLM 276_ IDSQN 281_ SKETE 286_ SHKAL 291_ SDLEL 296_ AAQSI 301_ IFIFA 306_ GYETT 311_ SSVLS 316_ FTLYE 321_ LATHP 326_ DVQQK 331_ LQKEI 336_ DAVLP 341_ NKAPP 346_ TYDAV 351_ VQMEY 356_ LDMVV 361_ NETLR 366_ LFPVA 371_ IRLER 376_ TCKKD 381_ VEING 386_ VFIPK 391_ GSMVV 396_ IPTYA 401_ LHHDP 406_ KYWTE 411_ PEEFR 416_ PERFS 421_ KKKDS 426_ IDPYI 431_ YTPFG 436_ TGPRN 441_ CIGMR 446_ FALMN 451_ MKLAL 456_ IRVLQ 461_ NFSFK 466_ PCKET 471_ QIPLK 476_ LDTQG 481_ LLQPE 486_ KPIVL 491_ KVDSR 496_DGTLS
1: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228)