Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
1_MVSKL 6_ SQLQT 11_ ELLAA 16_ LLESG 21_ LSKEA 26_ LIQAL 31_ GEPGP 36_ YLLAG 41_ EGPLD 46_ KGESC 51_ GGGRG 56_ ELAEL 61_ PNGLG 66_ ETRGS 71_ EDETD 76_ DDGED 81_ FTPPI 86_ LKELE 91_ NLSPE 96_ EAAHQ 101_ KAVVE 106_ TLLQE 111_ DPWRV 116_ AKMVK 121_ SYLQQ 126_ HNIPQ 131_ REVVD 136_ TTGLN 141_ QSHLS 146_ QHLNK 151_ GTPMK 156_ TQKRA 161_ ALYTW 166_ YVRKQ 171_ REVAQ 176_ QFTHA 181_ GQGGL 186_ IEEPT 191_ GDELP 196_ TKKGR 201_ RNRFK 206_ WGPAS 211_ QQILF 216_ QAYER 221_ QKNPS 226_ KEERE 231_ TLVEE 236_ CNRAE 241_ CIQRG 246_ VSPSQ 251_ AQGLG 256_ SNLVT 261_ EVRVY 266_ NWFAN 271_ RRKEE 276_ AFRHK 281_ LAMDT 286_ YSGPP 291_ PGPGP 296_ GPALP 301_ AHSSP 306_ GLPPP 311_ ALSPS 316_ KVHGV 321_ RYGQP 326_ ATSET 331_ AEVPS 336_ SSGGP 341_ LVTVS 346_ TPLHQ 351_ VSPTG 356_ LEPSH 361_ SLLST 366_ EAKLV 371_ SAAGG 376_ PLPPV 381_ STLTA 386_ LHSLE 391_ QTSPG 396_ LNQQP 401_ QNLIM 406_ ASLPG 411_ VMTIG 416_ PGEPA 421_ SLGPT 426_ FTNTG 431_ ASTLV 436_ IGLAS 441_ TQAQS 446_ VPVIN 451_ SMGSS 456_ LTTLQ 461_ PVQFS 466_ QPLHP 471_ SYQQP 476_ LMPPV 481_ QSHVT 486_ QSPFM 491_ ATMAQ 496_ LQSPH 501_ ALYSH 506_ KPEVA 511_ QYTHT 516_ GLLPQ 521_ TMLIT 526_ DTTNL 531_ SALAS 536_ LTPTK 541_ QVFTS 546_ DTEAS 551_ SESGL 556_ HTPAS 561_ QATTL 566_ HVPSQ 571_ DPAGI 576_ QHLQP 581_ AHRLS 586_ ASPTV 591_ SSSSL 596_ VLYQS 601_ SDSSN 606_ GQSHL 611_ LPSNH 616_ SVIET 621_ FISTQ 626_MASSS
1: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity)
2: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII)