Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)
1_MADYL 6_ ISGGT 11_ GYVPE 16_ DGLTA 21_ QQLFA 26_ SADGL 31_ TYNDF 36_ LILPG 41_ FIDFI 46_ ADEVD 51_ LTSAL 56_ TRKIT 61_ LKTPL 66_ ISSPM 71_ DTVTE 76_ ADMAI 81_ AMALM 86_ GGIGF 91_ IHHNC 96_ TPEFQ 101_ ANEVR 106_ KVKKF 111_ EQGFI 116_ TDPVV 121_ LSPSH 126_ TVGDV 131_ LEAKM 136_ RHGFS 141_ GIPIT 146_ ETGTM 151_ GSKLV 156_ GIVTS 161_ RDIDF 166_ LAEKD 171_ HTTLL 176_ SEVMT 181_ PRIEL 186_ VVAPA 191_ GVTLK 196_ EANEI 201_ LQRSK 206_ KGKLP 211_ IVNDC 216_ DELVA 221_ IIART 226_ DLKKN 231_ RDYPL 236_ ASKDS 241_ QKQLL 246_ CGAAV 251_ GTRED 256_ DKYRL 261_ DLLTQ 266_ AGVDV 271_ IVLDS 276_ SQGNS 281_ VYQIA 286_ MVHYI 291_ KQKYP 296_ HLQVI 301_ GGNVV 306_ TAAQA 311_ KNLID 316_ AGVDG 321_ LRVGM 326_ GCGSI 331_ CITQE 336_ VMACG 341_ RPQGT 346_ AVYKV 351_ AEYAR 356_ RFGVP 361_ IIADG 366_ GIQTV 371_ GHVVK 376_ ALALG 381_ ASTVM 386_ MGSLL 391_ AATTE 396_ APGEY 401_ FFSDG 406_ VRLKK 411_ YRGMG 416_ SLDAM 421_ EKSSS 426_ SQKRY 431_ FSEGD 436_ KVKIA 441_ QGVSG 446_ SIQDK 451_ GSIQK 456_ FVPYL 461_ IAGIQ 466_ HGCQD 471_ IGARS 476_ LSVLR 481_ SMMYS 486_ GELKF 491_ EKRTM 496_ SAQIE 501_ GGVHG 506_LHSYE
1: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors