Gene name: C4BPB

Uniprot entry:

P20851

Protein names:

C4b-binding protein beta chain

Protein sequence:

1_MFFWC 6_ ACCLM 11_ VAWRV 16_ SASDA 21_ EHCPE 26_ LPPVD 31_ NSIFV 36_ AKEVE 41_ GQILG 46_ TYVCI 51_ KGYHL 56_ VGKKT 61_ LFCNA 66_ SKEWD 71_ NTTTE 76_ CRLGH 81_ CPDPV 86_ LVNGE 91_ FSSSG 96_ PVNVS 101_ DKITF 106_ MCNDH 111_ YILKG 116_ SNRSQ 121_ CLEDH 126_ TWAPP 131_ FPICK 136_ SRDCD 141_ PPGNP 146_ VHGYF 151_ EGNNF 156_ TLGST 161_ ISYYC 166_ EDRYY 171_ LVGVQ 176_ EQQCV 181_ DGEWS 186_ SALPV 191_ CKLIQ 196_ EAPKP 201_ ECEKA 206_ LLAFQ 211_ ESKNL 216_ CEAME 221_ NFMQQ 226_ LKESG 231_ MTMEE 236_ LKYSL 241_ ELKKA 246_ELKAK

Protein annotations

Protein functions:

1: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S