Myelin-associated glycoprotein (Siglec-4a)
1_MIFLT 6_ ALPLF 11_ WIMIS 16_ ASRGG 21_ HWGAW 26_ MPSSI 31_ SAFEG 36_ TCVSI 41_ PCRFD 46_ FPDEL 51_ RPAVV 56_ HGVWY 61_ FNSPY 66_ PKNYP 71_ PVVFK 76_ SRTQV 81_ VHESF 86_ QGRSR 91_ LLGDL 96_ GLRNC 101_ TLLLS 106_ NVSPE 111_ LGGKY 116_ YFRGD 121_ LGGYN 126_ QYTFS 131_ EHSVL 136_ DIVNT 141_ PNIVV 146_ PPEVV 151_ AGTEV 156_ EVSCM 161_ VPDNC 166_ PELRP 171_ ELSWL 176_ GHEGL 181_ GEPAV 186_ LGRLR 191_ EDEGT 196_ WVQVS 201_ LLHFV 206_ PTREA 211_ NGHRL 216_ GCQAS 221_ FPNTT 226_ LQFEG 231_ YASMD 236_ VKYPP 241_ VIVEM 246_ NSSVE 251_ AIEGS 256_ HVSLL 261_ CGADS 266_ NPPPL 271_ LTWMR 276_ DGTVL 281_ REAVA 286_ ESLLL 291_ ELEEV 296_ TPAED 301_ GVYAC 306_ LAENA 311_ YGQDN 316_ RTVGL 321_ SVMYA 326_ PWKPT 331_ VNGTM 336_ VAVEG 341_ ETVSI 346_ LCSTQ 351_ SNPDP 356_ ILTIF 361_ KEKQI 366_ LSTVI 371_ YESEL 376_ QLELP 381_ AVSPE 386_ DDGEY 391_ WCVAE 396_ NQYGQ 401_ RATAF 406_ NLSVE 411_ FAPVL 416_ LLESH 421_ CAAAR 426_ DTVQC 431_ LCVVK 436_ SNPEP 441_ SVAFE 446_ LPSRN 451_ VTVNE 456_ SEREF 461_ VYSER 466_ SGLVL 471_ TSILT 476_ LRGQA 481_ QAPPR 486_ VICTA 491_ RNLYG 496_ AKSLE 501_ LPFQG 506_ AHRLM 511_ WAKIG 516_ PVGAV 521_ VAFAI 526_ LIAIV 531_ CYITQ 536_ TRRKK 541_ NVTES 546_ PSFSA 551_ GDNPP 556_ VLFSS 561_ DFRIS 566_ GAPEK 571_ YESER 576_ RLGSE 581_ RRLLG 586_ LRGEP 591_ PELDL 596_ SYSHS 601_ DLGKR 606_ PTKDS 611_ YTLTE 616_ ELAEY 621_AEIRV
1: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity)