3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)
1_MDPLG 6_ AAKPQ 11_ WPWRR 16_ CLAAL 21_ LFQLL 26_ VAVCF 31_ FSYLR 36_ VSRDD 41_ ATGSP 46_ RAPSG 51_ SSRQD 56_ TTPTR 61_ PTLLI 66_ LLWTW 71_ PFHIP 76_ VALSR 81_ CSEMV 86_ PGTAD 91_ CHITA 96_ DRKVY 101_ PQADT 106_ VIVHH 111_ WDIMS 116_ NPKSR 121_ LPPSP 126_ RPQGQ 131_ RWIWF 136_ NLEPP 141_ PNCQH 146_ LEALD 151_ RYFNL 156_ TMSYR 161_ SDSDI 166_ FTPYG 171_ WLEPW 176_ SGQPA 181_ HPPLN 186_ LSAKT 191_ ELVAW 196_ AVSNW 201_ KPDSA 206_ RVRYY 211_ QSLQA 216_ HLKVD 221_ VYGRS 226_ HKPLP 231_ KGTMM 236_ ETLSR 241_ YKFYL 246_ AFENS 251_ LHPDY 256_ ITEKL 261_ WRNAL 266_ EAWAV 271_ PVVLG 276_ PSRSN 281_ YERFL 286_ PPDAF 291_ IHVDD 296_ FQSPK 301_ DLARY 306_ LQELD 311_ KDHAR 316_ YLSYF 321_ RWRET 326_ LRPRS 331_ FSWAL 336_ DFCKA 341_ CWKLQ 346_ QESRY 351_ QTVRS 356_IAAWF
1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors (PubMed:11058871, PubMed:12668675, PubMed:1977660). Through its catalytic activity, participates in the synthesis of antigens of the Lewis blood group system, i.e. Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:11058871, PubMed:12668675, PubMed:1977660). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sLe(a) expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:11058871, PubMed:12668675, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871, PubMed:29593094). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660)