V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)
1_MALRA 6_ MRGIV 11_ NGAAP 16_ ELPVP 21_ TGGPA 26_ VGARE 31_ QALAV 36_ SRNYL 41_ SQPRL 46_ TYKTV 51_ SGVNG 56_ PLVIL 61_ DHVKF 66_ PRYAE 71_ IVHLT 76_ LPDGT 81_ KRSGQ 86_ VLEVS 91_ GSKAV 96_ VQVFE 101_ GTSGI 106_ DAKKT 111_ SCEFT 116_ GDILR 121_ TPVSE 126_ DMLGR 131_ VFNGS 136_ GKPID 141_ RGPVV 146_ LAEDF 151_ LDIMG 156_ QPINP 161_ QCRIY 166_ PEEMI 171_ QTGIS 176_ AIDGM 181_ NSIAR 186_ GQKIP 191_ IFSAA 196_ GLPHN 201_ EIAAQ 206_ ICRQA 211_ GLVKK 216_ SKDVV 221_ DYSEE 226_ NFAIV 231_ FAAMG 236_ VNMET 241_ ARFFK 246_ SDFEE 251_ NGSMD 256_ NVCLF 261_ LNLAN 266_ DPTIE 271_ RIITP 276_ RLALT 281_ TAEFL 286_ AYQCE 291_ KHVLV 296_ ILTDM 301_ SSYAE 306_ ALREV 311_ SAARE 316_ EVPGR 321_ RGFPG 326_ YMYTD 331_ LATIY 336_ ERAGR 341_ VEGRN 346_ GSITQ 351_ IPILT 356_ MPNDD 361_ ITHPI 366_ PDLTG 371_ YITEG 376_ QIYVD 381_ RQLHN 386_ RQIYP 391_ PINVL 396_ PSLSR 401_ LMKSA 406_ IGEGM 411_ TRKDH 416_ ADVSN 421_ QLYAC 426_ YAIGK 431_ DVQAM 436_ KAVVG 441_ EEALT 446_ SDDLL 451_ YLEFL 456_ QKFER 461_ NFIAQ 466_ GPYEN 471_ RTVFE 476_ TLDIG 481_ WQLLR 486_ IFPKE 491_ MLKRI 496_ PQSTL 501_ SEFYP 506_RDSAK
1: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity)