Gene name: ATP6V1C1

Uniprot entry:

P21283

Protein names:

V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)

Protein sequence:

1_MTEFW 6_ LISAP 11_ GEKTC 16_ QQTWE 21_ KLHAA 26_ TSKNN 31_ NLAVT 36_ SKFNI 41_ PDLKV 46_ GTLDV 51_ LVGLS 56_ DELAK 61_ LDAFV 66_ EGVVK 71_ KVAQY 76_ MADVL 81_ EDSKD 86_ KVQEN 91_ LLANG 96_ VDLVT 101_ YITRF 106_ QWDMA 111_ KYPIK 116_ QSLKN 121_ ISEII 126_ AKGVT 131_ QIDND 136_ LKSRA 141_ SAYNN 146_ LKGNL 151_ QNLER 156_ KNAGS 161_ LLTRS 166_ LAEIV 171_ KKDDF 176_ VLDSE 181_ YLVTL 186_ LVVVP 191_ KLNHN 196_ DWIKQ 201_ YETLA 206_ EMVVP 211_ RSSNV 216_ LSEDQ 221_ DSYLC 226_ NVTLF 231_ RKAVD 236_ DFRHK 241_ ARENK 246_ FIVRD 251_ FQYNE 256_ EEMKA 261_ DKEEM 266_ NRLST 271_ DKKKQ 276_ FGPLV 281_ RWLKV 286_ NFSEA 291_ FIAWI 296_ HVKAL 301_ RVFVE 306_ SVLRY 311_ GLPVN 316_ FQAML 321_ LQPNK 326_ KTLKK 331_ LREVL 336_ HELYK 341_ HLDSS 346_ AAAII 351_ DAPMD 356_ IPGLN 361_ LSQQE 366_ YYPYV 371_ YYKID 376_CNLLE

Protein annotations

Protein functions:

1: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)