Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
1_MSSSH 6_ SRAGQ 11_ SAAGA 16_ APGGG 21_ VDTRD 26_ AEMPA 31_ TEKDL 36_ AEDAP 41_ WKKIQ 46_ QNTFT 51_ RWCNE 56_ HLKCV 61_ SKRIA 66_ NLQTD 71_ LSDGL 76_ RLIAL 81_ LEVLS 86_ QKKMH 91_ RKHNQ 96_ RPTFR 101_ QMQLE 106_ NVSVA 111_ LEFLD 116_ RESIK 121_ LVSID 126_ SKAIV 131_ DGNLK 136_ LILGL 141_ IWTLI 146_ LHYSI 151_ SMPMW 156_ DEEED 161_ EEAKK 166_ QTPKQ 171_ RLLGW 176_ IQNKL 181_ PQLPI 186_ TNFSR 191_ DWQSG 196_ RALGA 201_ LVDSC 206_ APGLC 211_ PDWDS 216_ WDASK 221_ PVTNA 226_ REAMQ 231_ QADDW 236_ LGIPQ 241_ VITPE 246_ EIVDP 251_ NVDEH 256_ SVMTY 261_ LSQFP 266_ KAKLK 271_ PGAPL 276_ RPKLN 281_ PKKAR 286_ AYGPG 291_ IEPTG 296_ NMVKK 301_ RAEFT 306_ VETRS 311_ AGQGE 316_ VLVYV 321_ EDPAG 326_ HQEEA 331_ KVTAN 336_ NDKNR 341_ TFSVW 346_ YVPEV 351_ TGTHK 356_ VTVLF 361_ AGQHI 366_ AKSPF 371_ EVYVD 376_ KSQGD 381_ ASKVT 386_ AQGPG 391_ LEPSG 396_ NIANK 401_ TTYFE 406_ IFTAG 411_ AGTGE 416_ VEVVI 421_ QDPMG 426_ QKGTV 431_ EPQLE 436_ ARGDS 441_ TYRCS 446_ YQPTM 451_ EGVHT 456_ VHVTF 461_ AGVPI 466_ PRSPY 471_ TVTVG 476_ QACNP 481_ SACRA 486_ VGRGL 491_ QPKGV 496_ RVKET 501_ ADFKV 506_ YTKGA 511_ GSGEL 516_ KVTVK 521_ GPKGE 526_ ERVKQ 531_ KDLGD 536_ GVYGF 541_ EYYPM 546_ VPGTY 551_ IVTIT 556_ WGGQN 561_ IGRSP 566_ FEVKV 571_ GTECG 576_ NQKVR 581_ AWGPG 586_ LEGGV 591_ VGKSA 596_ DFVVE 601_ AIGDD 606_ VGTLG 611_ FSVEG 616_ PSQAK 621_ IECDD 626_ KGDGS 631_ CDVRY 636_ WPQEA 641_ GEYAV 646_ HVLCN 651_ SEDIR 656_ LSPFM 661_ ADIRD 666_ APQDF 671_ HPDRV 676_ KARGP 681_ GLEKT 686_ GVAVN 691_ KPAEF 696_ TVDAK 701_ HGGKA 706_ PLRVQ 711_ VQDNE 716_ GCPVE 721_ ALVKD 726_ NGNGT 731_ YSCSY 736_ VPRKP 741_ VKHTA 746_ MVSWG 751_ GVSIP 756_ NSPFR 761_ VNVGA 766_ GSHPN 771_ KVKVY 776_ GPGVA 781_ KTGLK 786_ AHEPT 791_ YFTVD 796_ CAEAG 801_ QGDVS 806_ IGIKC 811_ APGVV 816_ GPAEA 821_ DIDFD 826_ IIRND 831_ NDTFT 836_ VKYTP 841_ RGAGS 846_ YTIMV 851_ LFADQ 856_ ATPTS 861_ PIRVK 866_ VEPSH 871_ DASKV 876_ KAEGP 881_ GLSRT 886_ GVELG 891_ KPTHF 896_ TVNAK 901_ AAGKG 906_ KLDVQ 911_ FSGLT 916_ KGDAV 921_ RDVDI 926_ IDHHD 931_ NTYTV 936_ KYTPV 941_ QQGPV 946_ GVNVT 951_ YGGDP 956_ IPKSP 961_ FSVAV 966_ SPSLD 971_ LSKIK 976_ VSGLG 981_ EKVDV 986_ GKDQE 991_ FTVKS 996_ KGAGG 1001_ QGKVA 1006_ SKIVG 1011_ PSGAA 1016_ VPCKV 1021_ EPGLG 1026_ ADNSV 1031_ VRFLP 1036_ REEGP 1041_ YEVEV 1046_ TYDGV 1051_ PVPGS 1056_ PFPLE 1061_ AVAPT 1066_ KPSKV 1071_ KAFGP 1076_ GLQGG 1081_ SAGSP 1086_ ARFTI 1091_ DTKGA 1096_ GTGGL 1101_ GLTVE 1106_ GPCEA 1111_ QLECL 1116_ DNGDG 1121_ TCSVS 1126_ YVPTE 1131_ PGDYN 1136_ INILF 1141_ ADTHI 1146_ PGSPF 1151_ KAHVV 1156_ PCFDA 1161_ SKVKC 1166_ SGPGL 1171_ ERATA 1176_ GEVGQ 1181_ FQVDC 1186_ SSAGS 1191_ AELTI 1196_ EICSE 1201_ AGLPA 1206_ EVYIQ 1211_ DHGDG 1216_ THTIT 1221_ YIPLC 1226_ PGAYT 1231_ VTIKY 1236_ GGQPV 1241_ PNFPS 1246_ KLQVE 1251_ PAVDT 1256_ SGVQC 1261_ YGPGI 1266_ EGQGV 1271_ FREAT 1276_ TEFSV 1281_ DARAL 1286_ TQTGG 1291_ PHVKA 1296_ RVANP 1301_ SGNLT 1306_ ETYVQ 1311_ DRGDG 1316_ MYKVE 1321_ YTPYE 1326_ EGLHS 1331_ VDVTY 1336_ DGSPV 1341_ PSSPF 1346_ QVPVT 1351_ EGCDP 1356_ SRVRV 1361_ HGPGI 1366_ QSGTT 1371_ NKPNK 1376_ FTVET 1381_ RGAGT 1386_ GGLGL 1391_ AVEGP 1396_ SEAKM 1401_ SCMDN 1406_ KDGSC 1411_ SVEYI 1416_ PYEAG 1421_ TYSLN 1426_ VTYGG 1431_ HQVPG 1436_ SPFKV 1441_ PVHDV 1446_ TDASK 1451_ VKCSG 1456_ PGLSP 1461_ GMVRA 1466_ NLPQS 1471_ FQVDT 1476_ SKAGV 1481_ APLQV 1486_ KVQGP 1491_ KGLVE 1496_ PVDVV 1501_ DNADG 1506_ TQTVN 1511_ YVPSR 1516_ EGPYS 1521_ ISVLY 1526_ GDEEV 1531_ PRSPF 1536_ KVKVL 1541_ PTHDA 1546_ SKVKA 1551_ SGPGL 1556_ NTTGV 1561_ PASLP 1566_ VEFTI 1571_ DAKDA 1576_ GEGLL 1581_ AVQIT 1586_ DPEGK 1591_ PKKTH 1596_ IQDNH 1601_ DGTYT 1606_ VAYVP 1611_ DVTGR 1616_ YTILI 1621_ KYGGD 1626_ EIPFS 1631_ PYRVR 1636_ AVPTG 1641_ DASKC 1646_ TVTVS 1651_ IGGHG 1656_ LGAGI 1661_ GPTIQ 1666_ IGEET 1671_ VITVD 1676_ TKAAG 1681_ KGKVT 1686_ CTVCT 1691_ PDGSE 1696_ VDVDV 1701_ VENED 1706_ GTFDI 1711_ FYTAP 1716_ QPGKY 1721_ VICVR 1726_ FGGEH 1731_ VPNSP 1736_ FQVTA 1741_ LAGDQ 1746_ PSVQP 1751_ PLRSQ 1756_ QLAPQ 1761_ YTYAQ 1766_ GGQQT 1771_ WAPER 1776_ PLVGV 1781_ NGLDV 1786_ TSLRP 1791_ FDLVI 1796_ PFTIK 1801_ KGEIT 1806_ GEVRM 1811_ PSGKV 1816_ AQPTI 1821_ TDNKD 1826_ GTVTV 1831_ RYAPS 1836_ EAGLH 1841_ EMDIR 1846_ YDNMH 1851_ IPGSP 1856_ LQFYV 1861_ DYVNC 1866_ GHVTA 1871_ YGPGL 1876_ THGVV 1881_ NKPAT 1886_ FTVNT 1891_ KDAGE 1896_ GGLSL 1901_ AIEGP 1906_ SKAEI 1911_ SCTDN 1916_ QDGTC 1921_ SVSYL 1926_ PVLPG 1931_ DYSIL 1936_ VKYNE 1941_ QHVPG 1946_ SPFTA 1951_ RVTGD 1956_ DSMRM 1961_ SHLKV 1966_ GSAAD 1971_ IPINI 1976_ SETDL 1981_ SLLTA 1986_ TVVPP 1991_ SGREE 1996_ PCLLK 2001_ RLRNG 2006_ HVGIS 2011_ FVPKE 2016_ TGEHL 2021_ VHVKK 2026_ NGQHV 2031_ ASSPI 2036_ PVVIS 2041_ QSEIG 2046_ DASRV 2051_ RVSGQ 2056_ GLHEG 2061_ HTFEP 2066_ AEFII 2071_ DTRDA 2076_ GYGGL 2081_ SLSIE 2086_ GPSKV 2091_ DINTE 2096_ DLEDG 2101_ TCRVT 2106_ YCPTE 2111_ PGNYI 2116_ INIKF 2121_ ADQHV 2126_ PGSPF 2131_ SVKVT 2136_ GEGRV 2141_ KESIT 2146_ RRRRA 2151_ PSVAN 2156_ VGSHC 2161_ DLSLK 2166_ IPEIS 2171_ IQDMT 2176_ AQVTS 2181_ PSGKT 2186_ HEAEI 2191_ VEGEN 2196_ HTYCI 2201_ RFVPA 2206_ EMGTH 2211_ TVSVK 2216_ YKGQH 2221_ VPGSP 2226_ FQFTV 2231_ GPLGE 2236_ GGAHK 2241_ VRAGG 2246_ PGLER 2251_ AEAGV 2256_ PAEFS 2261_ IWTRE 2266_ AGAGG 2271_ LAIAV 2276_ EGPSK 2281_ AEISF 2286_ EDRKD 2291_ GSCGV 2296_ AYVVQ 2301_ EPGDY 2306_ EVSVK 2311_ FNEEH 2316_ IPDSP 2321_ FVVPV 2326_ ASPSG 2331_ DARRL 2336_ TVSSL 2341_ QESGL 2346_ KVNQP 2351_ ASFAV 2356_ SLNGA 2361_ KGAID 2366_ AKVHS 2371_ PSGAL 2376_ EECYV 2381_ TEIDQ 2386_ DKYAV 2391_ RFIPR 2396_ ENGVY 2401_ LIDVK 2406_ FNGTH 2411_ IPGSP 2416_ FKIRV 2421_ GEPGH 2426_ GGDPG 2431_ LVSAY 2436_ GAGLE 2441_ GGVTG 2446_ NPAEF 2451_ VVNTS 2456_ NAGAG 2461_ ALSVT 2466_ IDGPS 2471_ KVKMD 2476_ CQECP 2481_ EGYRV 2486_ TYTPM 2491_ APGSY 2496_ LISIK 2501_ YGGPY 2506_ HIGGS 2511_ PFKAK 2516_ VTGPR 2521_ LVSNH 2526_ SLHET 2531_ SSVFV 2536_ DSLTK 2541_ ATCAP 2546_ QHGAP 2551_ GPGPA 2556_ DASKV 2561_ VAKGL 2566_ GLSKA 2571_ YVGQK 2576_ SSFTV 2581_ DCSKA 2586_ GNNML 2591_ LVGVH 2596_ GPRTP 2601_ CEEIL 2606_ VKHVG 2611_ SRLYS 2616_ VSYLL 2621_ KDKGE 2626_ YTLVV 2631_ KWGDE 2636_ HIPGS 2641_PYRVV
1: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863)