Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)
1_MSNPF 6_ AHLAE 11_ PLDPV 16_ QPGKK 21_ FFNLN 26_ KLEDS 31_ RYGRL 36_ PFSIR 41_ VLLEA 46_ AIRNC 51_ DEFLV 56_ KKQDI 61_ ENILH 66_ WNVTQ 71_ HKNIE 76_ VPFKP 81_ ARVIL 86_ QDFTG 91_ VPAVV 96_ DFAAM 101_ RDAVK 106_ KLGGD 111_ PEKIN 116_ PVCPA 121_ DLVID 126_ HSIQV 131_ DFNRR 136_ ADSLQ 141_ KNQDL 146_ EFERN 151_ RERFE 156_ FLKWG 161_ SQAFH 166_ NMRII 171_ PPGSG 176_ IIHQV 181_ NLEYL 186_ ARVVF 191_ DQDGY 196_ YYPDS 201_ LVGTD 206_ SHTTM 211_ IDGLG 216_ ILGWG 221_ VGGIE 226_ AEAVM 231_ LGQPI 236_ SMVLP 241_ QVIGY 246_ RLMGK 251_ PHPLV 256_ TSTDI 261_ VLTIT 266_ KHLRQ 271_ VGVVG 276_ KFVEF 281_ FGPGV 286_ AQLSI 291_ ADRAT 296_ IANMC 301_ PEYGA 306_ TAAFF 311_ PVDEV 316_ SITYL 321_ VQTGR 326_ DEEKL 331_ KYIKK 336_ YLQAV 341_ GMFRD 346_ FNDPS 351_ QDPDF 356_ TQVVE 361_ LDLKT 366_ VVPCC 371_ SGPKR 376_ PQDKV 381_ AVSDM 386_ KKDFE 391_ SCLGA 396_ KQGFK 401_ GFQVA 406_ PEHHN 411_ DHKTF 416_ IYDNT 421_ EFTLA 426_ HGSVV 431_ IAAIT 436_ SCTNT 441_ SNPSV 446_ MLGAG 451_ LLAKK 456_ AVDAG 461_ LNVMP 466_ YIKTS 471_ LSPGS 476_ GVVTY 481_ YLQES 486_ GVMPY 491_ LSQLG 496_ FDVVG 501_ YGCMT 506_ CIGNS 511_ GPLPE 516_ PVVEA 521_ ITQGD 526_ LVAVG 531_ VLSGN 536_ RNFEG 541_ RVHPN 546_ TRANY 551_ LASPP 556_ LVIAY 561_ AIAGT 566_ IRIDF 571_ EKEPL 576_ GVNAK 581_ GQQVF 586_ LKDIW 591_ PTRDE 596_ IQAVE 601_ RQYVI 606_ PGMFK 611_ EVYQK 616_ IETVN 621_ ESWNA 626_ LATPS 631_ DKLFF 636_ WNSKS 641_ TYIKS 646_ PPFFE 651_ NLTLD 656_ LQPPK 661_ SIVDA 666_ YVLLN 671_ LGDSV 676_ TTDHI 681_ SPAGN 686_ IARNS 691_ PAARY 696_ LTNRG 701_ LTPRE 706_ FNSYG 711_ SRRGN 716_ DAVMA 721_ RGTFA 726_ NIRLL 731_ NRFLN 736_ KQAPQ 741_ TIHLP 746_ SGEIL 751_ DVFDA 756_ AERYQ 761_ QAGLP 766_ LIVLA 771_ GKEYG 776_ AGSSR 781_ DWAAK 786_ GPFLL 791_ GIKAV 796_ LAESY 801_ ERIHR 806_ SNLVG 811_ MGVIP 816_ LEYLP 821_ GENAD 826_ ALGLT 831_ GQERY 836_ TIIIP 841_ ENLKP 846_ QMKVQ 851_ VKLDT 856_ GKTFQ 861_ AVMRF 866_ DTDVE 871_ LTYFL 876_ NGGIL 881_NYMIR
1: Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788)
2: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate