Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
1_MDLEA 6_ AKNGT 11_ AWRPT 16_ SAEGD 21_ FELGI 26_ SSKQK 31_ RKKTK 36_ TVKMI 41_ GVLTL 46_ FRYSD 51_ WQDKL 56_ FMSLG 61_ TIMAI 66_ AHGSG 71_ LPLMM 76_ IVFGE 81_ MTDKF 86_ VDTAG 91_ NFSFP 96_ VNFSL 101_ SLLNP 106_ GKILE 111_ EEMTR 116_ YAYYY 121_ SGLGA 126_ GVLVA 131_ AYIQV 136_ SFWTL 141_ AAGRQ 146_ IRKIR 151_ QKFFH 156_ AILRQ 161_ EIGWF 166_ DINDT 171_ TELNT 176_ RLTDD 181_ ISKIS 186_ EGIGD 191_ KVGMF 196_ FQAVA 201_ TFFAG 206_ FIVGF 211_ IRGWK 216_ LTLVI 221_ MAISP 226_ ILGLS 231_ AAVWA 236_ KILSA 241_ FSDKE 246_ LAAYA 251_ KAGAV 256_ AEEAL 261_ GAIRT 266_ VIAFG 271_ GQNKE 276_ LERYQ 281_ KHLEN 286_ AKEIG 291_ IKKAI 296_ SANIS 301_ MGIAF 306_ LLIYA 311_ SYALA 316_ FWYGS 321_ TLVIS 326_ KEYTI 331_ GNAMT 336_ VFFSI 341_ LIGAF 346_ SVGQA 351_ APCID 356_ AFANA 361_ RGAAY 366_ VIFDI 371_ IDNNP 376_ KIDSF 381_ SERGH 386_ KPDSI 391_ KGNLE 396_ FNDVH 401_ FSYPS 406_ RANVK 411_ ILKGL 416_ NLKVQ 421_ SGQTV 426_ ALVGS 431_ SGCGK 436_ STTVQ 441_ LIQRL 446_ YDPDE 451_ GTINI 456_ DGQDI 461_ RNFNV 466_ NYLRE 471_ IIGVV 476_ SQEPV 481_ LFSTT 486_ IAENI 491_ CYGRG 496_ NVTMD 501_ EIKKA 506_ VKEAN 511_ AYEFI 516_ MKLPQ 521_ KFDTL 526_ VGERG 531_ AQLSG 536_ GQKQR 541_ IAIAR 546_ ALVRN 551_ PKILL 556_ LDEAT 561_ SALDT 566_ ESEAE 571_ VQAAL 576_ DKARE 581_ GRTTI 586_ VIAHR 591_ LSTVR 596_ NADVI 601_ AGFED 606_ GVIVE 611_ QGSHS 616_ ELMKK 621_ EGVYF 626_ KLVNM 631_ QTSGS 636_ QIQSE 641_ EFELN 646_ DEKAA 651_ TRMAP 656_ NGWKS 661_ RLFRH 666_ STQKN 671_ LKNSQ 676_ MCQKS 681_ LDVET 686_ DGLEA 691_ NVPPV 696_ SFLKV 701_ LKLNK 706_ TEWPY 711_ FVVGT 716_ VCAIA 721_ NGGLQ 726_ PAFSV 731_ IFSEI 736_ IAIFG 741_ PGDDA 746_ VKQQK 751_ CNIFS 756_ LIFLF 761_ LGIIS 766_ FFTFF 771_ LQGFT 776_ FGKAG 781_ EILTR 786_ RLRSM 791_ AFKAM 796_ LRQDM 801_ SWFDD 806_ HKNST 811_ GALST 816_ RLATD 821_ AAQVQ 826_ GATGT 831_ RLALI 836_ AQNIA 841_ NLGTG 846_ IIISF 851_ IYGWQ 856_ LTLLL 861_ LAVVP 866_ IIAVS 871_ GIVEM 876_ KLLAG 881_ NAKRD 886_ KKELE 891_ AAGKI 896_ ATEAI 901_ ENIRT 906_ VVSLT 911_ QERKF 916_ ESMYV 921_ EKLYG 926_ PYRNS 931_ VQKAH 936_ IYGIT 941_ FSISQ 946_ AFMYF 951_ SYAGC 956_ FRFGA 961_ YLIVN 966_ GHMRF 971_ RDVIL 976_ VFSAI 981_ VFGAV 986_ ALGHA 991_ SSFAP 996_ DYAKA 1001_ KLSAA 1006_ HLFML 1011_ FERQP 1016_ LIDSY 1021_ SEEGL 1026_ KPDKF 1031_ EGNIT 1036_ FNEVV 1041_ FNYPT 1046_ RANVP 1051_ VLQGL 1056_ SLEVK 1061_ KGQTL 1066_ ALVGS 1071_ SGCGK 1076_ STVVQ 1081_ LLERF 1086_ YDPLA 1091_ GTVFV 1096_ DFGFQ 1101_ LLDGQ 1106_ EAKKL 1111_ NVQWL 1116_ RAQLG 1121_ IVSQE 1126_ PILFD 1131_ CSIAE 1136_ NIAYG 1141_ DNSRV 1146_ VSQDE 1151_ IVSAA 1156_ KAANI 1161_ HPFIE 1166_ TLPHK 1171_ YETRV 1176_ GDKGT 1181_ QLSGG 1186_ QKQRI 1191_ AIARA 1196_ LIRQP 1201_ QILLL 1206_ DEATS 1211_ ALDTE 1216_ SEKVV 1221_ QEALD 1226_ KAREG 1231_ RTCIV 1236_ IAHRL 1241_ STIQN 1246_ ADLIV 1251_ VFQNG 1256_ RVKEH 1261_ GTHQQ 1266_ LLAQK 1271_ GIYFS 1276_ MVSVQ 1281_AGTQN
1: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:17523162, PubMed:21820390, PubMed:23468132, PubMed:24594635, PubMed:24723470, PubMed:24806754, PubMed:31873305, PubMed:7957936, PubMed:8898203, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:28012258, PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity)