Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)
1_MGTCD 6_ IVTEA 11_ NISSG 16_ PESNT 21_ TGITA 26_ FSMPS 31_ WQLAL 36_ WATAY 41_ LALVL 46_ VAVTG 51_ NAIVI 56_ WIILA 61_ HRRMR 66_ TVTNY 71_ FIVNL 76_ ALADL 81_ CMAAF 86_ NAAFN 91_ FVYAS 96_ HNIWY 101_ FGRAF 106_ CYFQN 111_ LFPIT 116_ AMFVS 121_ IYSMT 126_ AIAAD 131_ RYMAI 136_ VHPFQ 141_ PRLSA 146_ PSTKA 151_ VIAGI 156_ WLVAL 161_ ALASP 166_ QCFYS 171_ TVTMD 176_ QGATK 181_ CVVAW 186_ PEDSG 191_ GKTLL 196_ LYHLV 201_ VIALI 206_ YFLPL 211_ AVMFV 216_ AYSVI 221_ GLTLW 226_ RRAVP 231_ GHQAH 236_ GANLR 241_ HLQAM 246_ KKFVK 251_ TMVLV 256_ VLTFA 261_ ICWLP 266_ YHLYF 271_ ILGSF 276_ QEDIY 281_ CHKFI 286_ QQVYL 291_ ALFWL 296_ AMSST 301_ MYNPI 306_ IYCCL 311_ NHRFR 316_ SGFRL 321_ AFRCC 326_ PWVTP 331_ TKEDK 336_ LELTP 341_ TTSLS 346_ TRVNR 351_ CHTKE 356_ TLFMA 361_ GDTAP 366_ SEATS 371_ GEAGR 376_ PQDGS 381_ GLWFG 386_ YGLLA 391_PTKTH
1: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P