Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
1_MGPTS 6_ VPLVK 11_ AHRSS 16_ VSDYV 21_ NYDII 26_ VRHYN 31_ YTGKL 36_ NISAD 41_ KENSI 46_ KLTSV 51_ VFILI 56_ CCFII 61_ LENIF 66_ VLLTI 71_ WKTKK 76_ FHRPM 81_ YYFIG 86_ NLALS 91_ DLLAG 96_ VAYTA 101_ NLLLS 106_ GATTY 111_ KLTPA 116_ QWFLR 121_ EGSMF 126_ VALSA 131_ SVFSL 136_ LAIAI 141_ ERYIT 146_ MLKMK 151_ LHNGS 156_ NNFRL 161_ FLLIS 166_ ACWVI 171_ SLILG 176_ GLPIM 181_ GWNCI 186_ SALSS 191_ CSTVL 196_ PLYHK 201_ HYILF 206_ CTTVF 211_ TLLLL 216_ SIVIL 221_ YCRIY 226_ SLVRT 231_ RSRRL 236_ TFRKN 241_ ISKAS 246_ RSSEK 251_ SLALL 256_ KTVII 261_ VLSVF 266_ IACWA 271_ PLFIL 276_ LLLDV 281_ GCKVK 286_ TCDIL 291_ FRAEY 296_ FLVLA 301_ VLNSG 306_ TNPII 311_ YTLTN 316_ KEMRR 321_ AFIRI 326_ MSCCK 331_ CPSGD 336_ SAGKF 341_ KRPII 346_ AGMEF 351_ SRSKS 356_ DNSSH 361_ PQKDE 366_ GDNPE 371_ TIMSS 376_GNVNS
1: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury