fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor)
1_METNS 6_ SLPTN 11_ ISGGT 16_ PAVSA 21_ GYLFL 26_ DIITY 31_ LVFAV 36_ TFVLG 41_ VLGNG 46_ LVIWV 51_ AGFRM 56_ THTVT 61_ TISYL 66_ NLAVA 71_ DFCFT 76_ STLPF 81_ FMVRK 86_ AMGGH 91_ WPFGW 96_ FLCKF 101_ VFTIV 106_ DINLF 111_ GSVFL 116_ IALIA 121_ LDRCV 126_ CVLHP 131_ VWTQN 136_ HRTVS 141_ LAKKV 146_ IIGPW 151_ VMALL 156_ LTLPV 161_ IIRVT 166_ TVPGK 171_ TGTVA 176_ CTFNF 181_ SPWTN 186_ DPKER 191_ INVAV 196_ AMLTV 201_ RGIIR 206_ FIIGF 211_ SAPMS 216_ IVAVS 221_ YGLIA 226_ TKIHK 231_ QGLIK 236_ SSRPL 241_ RVLSF 246_ VAAAF 251_ FLCWS 256_ PYQVV 261_ ALIAT 266_ VRIRE 271_ LLQGM 276_ YKEIG 281_ IAVDV 286_ TSALA 291_ FFNSC 296_ LNPML 301_ YVFMG 306_ QDFRE 311_ RLIHA 316_ LPASL 321_ ERALT 326_ EDSTQ 331_ TSDTA 336_ TNSTL 341_PSAEV
1: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:15153520, PubMed:15210802, PubMed:1712023, PubMed:2161213). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:10514456, PubMed:1712023). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802)