Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)
1_MVSES 6_ HHEAL 11_ AAPPV 16_ TTVAT 21_ VLPSN 26_ ATEPA 31_ SPGEG 36_ KEDAF 41_ SKLKE 46_ KFMNE 51_ LHKIP 56_ LPPWA 61_ LIAIA 66_ IVAVL 71_ LVLTC 76_ CFCIC 81_ KKCLF 86_ KKKNK 91_ KKGKE 96_ KGGKN 101_ AINMK 106_ DVKDL 111_ GKTMK 116_ DQALK 121_ DDDAE 126_ TGLTD 131_ GEEKE 136_ EPKEE 141_ EKLGK 146_ LQYSL 151_ DYDFQ 156_ NNQLL 161_ VGIIQ 166_ AAELP 171_ ALDMG 176_ GTSDP 181_ YVKVF 186_ LLPDK 191_ KKKFE 196_ TKVHR 201_ KTLNP 206_ VFNEQ 211_ FTFKV 216_ PYSEL 221_ GGKTL 226_ VMAVY 231_ DFDRF 236_ SKHDI 241_ IGEFK 246_ VPMNT 251_ VDFGH 256_ VTEEW 261_ RDLQS 266_ AEKEE 271_ QEKLG 276_ DICFS 281_ LRYVP 286_ TAGKL 291_ TVVIL 296_ EAKNL 301_ KKMDV 306_ GGLSD 311_ PYVKI 316_ HLMQN 321_ GKRLK 326_ KKKTT 331_ IKKNT 336_ LNPYY 341_ NESFS 346_ FEVPF 351_ EQIQK 356_ VQVVV 361_ TVLDY 366_ DKIGK 371_ NDAIG 376_ KVFVG 381_ YNSTG 386_ AELRH 391_ WSDML 396_ ANPRR 401_ PIAQW 406_ HTLQV 411_ EEEVD 416_AMLAV
1: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)