Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)
1_MAKFV 6_ IRPAT 11_ AADCS 16_ DILRL 21_ IKELA 26_ KYEYM 31_ EEQVI 36_ LTEKD 41_ LLEDG 46_ FGEHP 51_ FYHCL 56_ VAEVP 61_ KEHWT 66_ PEGHS 71_ IVGFA 76_ MYYFT 81_ YDPWI 86_ GKLLY 91_ LEDFF 96_ VMSDY 101_ RGFGI 106_ GSEIL 111_ KNLSQ 116_ VAMRC 121_ RCSSM 126_ HFLVA 131_ EWNEP 136_ SINFY 141_ KRRGA 146_ SDLSS 151_ EEGWR 156_ LFKID 161_ KEYLL 166_KMATE
1: Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632)