Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
1_MGPGC 6_ DLLLR 11_ TAATI 16_ TAAAI 21_ MSDTD 26_ SDEDS 31_ AGGGP 36_ FSLAG 41_ FLFGN 46_ INGAG 51_ QLEGE 56_ SVLDD 61_ ECKKH 66_ LAGLG 71_ ALGLG 76_ SLITE 81_ LTANE 86_ ELTGT 91_ DGALV 96_ NDEGW 101_ VRSTE 106_ DAVDY 111_ SDINE 116_ VAEDE 121_ SRRYQ 126_ QTMGS 131_ LQPLC 136_ HSDYD 141_ EDDYD 146_ ADCED 151_ IDCKL 156_ MPPPP 161_ PPPGP 166_ MKKDK 171_ DQDSI 176_ TGEKV 181_ DFSSS 186_ SDSES 191_ EMGPQ 196_ EATQA 201_ ESEDG 206_ KLTLP 211_ LAGIM 216_ QHDAT 221_ KLLPS 226_ VTELF 231_ PEFRP 236_ GKVLR 241_ FLRLF 246_ GPGKN 251_ VPSVW 256_ RSARR 261_ KRKKK 266_ HRELI 271_ QEEQI 276_ QEVEC 281_ SVESE 286_ VSQKS 291_ LWNYD 296_ YAPPP 301_ PPEQC 306_ LSDDE 311_ ITMMA 316_ PVESK 321_ FSQST 326_ GDIDK 331_ VTDTK 336_ PRVAE 341_ WRYGP 346_ ARLWY 351_ DMLGV 356_ PEDGS 361_ GFDYG 366_ FKLRK 371_ TEHEP 376_ VIKSR 381_ MIEEF 386_ RKLEE 391_ NNGTD 396_ LLADE 401_ NFLMV 406_ TQLHW 411_ EDDII 416_ WDGED 421_ VKHKG 426_ TKPQR 431_ ASLAG 436_ WLPSS 441_ MTRNA 446_ MAYNV 451_ QQGFA 456_ ATLDD 461_ DKPWY 466_ SIFPI 471_ DNEDL 476_ VYGRW 481_ EDNII 486_ WDAQA 491_ MPRLL 496_ EPPVL 501_ TLDPN 506_ DENLI 511_ LEIPD 516_ EKEEA 521_ TSNSP 526_ SKESK 531_ KESSL 536_ KKSRI 541_ LLGKT 546_ GVIKE 551_ EPQQN 556_ MSQPE 561_ VKDPW 566_ NLSND 571_ EYYYP 576_ KQQGL 581_ RGTFG 586_ GNIIQ 591_ HSIPA 596_ VELRQ 601_ PFFPT 606_ HMGPI 611_ KLRQF 616_ HRPPL 621_ KKYSF 626_ GALSQ 631_ PGPHS 636_ VQPLL 641_ KHIKK 646_ KAKMR 651_ EQERQ 656_ ASGGG 661_ EMFFM 666_ RTPQD 671_ LTGKD 676_ GDLIL 681_ AEYSE 686_ ENGPL 691_ MMQVG 696_ MATKI 701_ KNYYK 706_ RKPGK 711_ DPGAP 716_ DCKYG 721_ ETVYC 726_ HTSPF 731_ LGSLH 736_ PGQLL 741_ QAFEN 746_ NLFRA 751_ PIYLH 756_ KMPET 761_ DFLII 766_ RTRQG 771_ YYIRE 776_ LVDIF 781_ VVGQQ 786_ CPLFE 791_ VPGPN 796_ SKRAN 801_ THIRD 806_ FLQVF 811_ IYRLF 816_ WKSKD 821_ RPRRI 826_ RMEDI 831_ KKAFP 836_ SHSES 841_ SIRKR 846_ LKLCA 851_ DFKRT 856_ GMDSN 861_ WWVLK 866_ SDFRL 871_ PTEEE 876_ IRAMV 881_ SPEQC 886_ CAYYS 891_ MIAAE 896_ QRLKD 901_ AGYGE 906_ KSFFA 911_ PEEEN 916_ EEDFQ 921_ MKIDD 926_ EVRTA 931_ PWNTT 936_ RAFIA 941_ AMKGK 946_ CLLEV 951_ TGVAD 956_ PTGCG 961_ EGFSY 966_ VKIPN 971_ KPTQQ 976_ KDDKE 981_ PQPVK 986_ KTVTG 991_ TDADL 996_ RRLSL 1001_ KNAKQ 1006_ LLRKF 1011_ GVPEE 1016_ EIKKL 1021_ SRWEV 1026_ IDVVR 1031_ TMSTE 1036_ QARSG 1041_ EGPMS 1046_ KFARG 1051_ SRFSV 1056_ AEHQE 1061_ RYKEE 1066_ CQRIF 1071_ DLQNK 1076_ VLSST 1081_ EVLST 1086_ DTDSS 1091_ SAEDS 1096_ DFEEM 1101_ GKNIE 1106_ NMLQN 1111_ KKTSS 1116_ QLSRE 1121_ REEQE 1126_ RKELQ 1131_ RMLLA 1136_ AGSAA 1141_ SGNNH 1146_ RDDDT 1151_ ASVTS 1156_ LNSSA 1161_ TGRCL 1166_ KIYRT 1171_ FRDEE 1176_ GKEYV 1181_ RCETV 1186_ RKPAV 1191_ IDAYV 1196_ RIRTT 1201_ KDEEF 1206_ IRKFA 1211_ LFDEQ 1216_ HREEM 1221_ RKERR 1226_ RIQEQ 1231_ LRRLK 1236_ RNQEK 1241_ EKLKG 1246_ PPEKK 1251_ PKKMK 1256_ ERPDL 1261_ KLKCG 1266_ ACGAI 1271_ GHMRT 1276_ NKFCP 1281_ LYYQT 1286_ NAPPS 1291_ NPVAM 1296_ TEEQE 1301_ EELEK 1306_ TVIHN 1311_ DNEEL 1316_ IKVEG 1321_ TKIVL 1326_ GKQLI 1331_ ESADE 1336_ VRRKS 1341_ LVLKF 1346_ PKQQL 1351_ PPKKK 1356_ RRVGT 1361_ TVHCD 1366_ YLNRP 1371_ HKSIH 1376_ RRRTD 1381_ PMVTL 1386_ SSILE 1391_ SIIND 1396_ MRDLP 1401_ NTYPF 1406_ HTPVN 1411_ AKVVK 1416_ DYYKI 1421_ ITRPM 1426_ DLQTL 1431_ RENVR 1436_ KRLYP 1441_ SREEF 1446_ REHLE 1451_ LIVKN 1456_ SATYN 1461_ GPKHS 1466_ LTQIS 1471_ QSMLD 1476_ LCDEK 1481_ LKEKE 1486_ DKLAR 1491_ LEKAI 1496_ NPLLD 1501_ DDDQV 1506_ AFSFI 1511_ LDNIV 1516_ TQKMM 1521_ AVPDS 1526_ WPFHH 1531_ PVNKK 1536_ FVPDY 1541_ YKVIV 1546_ NPMDL 1551_ ETIRK 1556_ NISKH 1561_ KYQSR 1566_ ESFLD 1571_ DVNLI 1576_ LANSV 1581_ KYNGP 1586_ ESQYT 1591_ KTAQE 1596_ IVNVC 1601_ YQTLT 1606_ EYDEH 1611_ LTQLE 1616_ KDICT 1621_ AKEAA 1626_ LEEAE 1631_ LESLD 1636_ PMTPG 1641_ PYTPQ 1646_ PPDLY 1651_ DTNTS 1656_ LSMSR 1661_ DASVF 1666_ QDESN 1671_ MSVLD 1676_ IPSAT 1681_ PEKQV 1686_ TQEGE 1691_ DGDGD 1696_ LADEE 1701_ EGTVQ 1706_ QPQAS 1711_ VLYED 1716_ LLMSE 1721_ GEDDE 1726_ EDAGS 1731_ DEEGD 1736_ NPFSA 1741_ IQLSE 1746_ SGSDS 1751_ DVGSG 1756_ GIRPK 1761_ QPRML 1766_ QENTR 1771_ MDMEN 1776_ EESMM 1781_ SYEGD 1786_ GGEAS 1791_ HGLED 1796_ SNISY 1801_ GSYEE 1806_ PDPKS 1811_ NTQDT 1816_ SFSSI 1821_ GGYEV 1826_ SEEEE 1831_ DEEEE 1836_ EQRSG 1841_ PSVLS 1846_ QVHLS 1851_ EDEED 1856_ SEDFH 1861_ SIAGD 1866_SDLDS
1: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659). Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300)