Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
1_MERRW 6_ PLGLG 11_ LVLLL 16_ CAPLP 21_ PGARA 26_ KEVTL 31_ MDTSK 36_ AQGEL 41_ GWLLD 46_ PPKDG 51_ WSEQQ 56_ QILNG 61_ TPLYM 66_ YQDCP 71_ MQGRR 76_ DTDHW 81_ LRSNW 86_ IYRGE 91_ EASRV 96_ HVELQ 101_ FTVRD 106_ CKSFP 111_ GGAGP 116_ LGCKE 121_ TFNLL 126_ YMESD 131_ QDVGI 136_ QLRRP 141_ LFQKV 146_ TTVAA 151_ DQSFT 156_ IRDLV 161_ SGSVK 166_ LNVER 171_ CSLGR 176_ LTRRG 181_ LYLAF 186_ HNPGA 191_ CVALV 196_ SVRVF 201_ YQRCP 206_ ETLNG 211_ LAQFP 216_ DTLPG 221_ PAGLV 226_ EVAGT 231_ CLPHA 236_ RASPR 241_ PSGAP 246_ RMHCS 251_ PDGEW 256_ LVPVG 261_ RCHCE 266_ PGYEE 271_ GGSGE 276_ ACVAC 281_ PSGSY 286_ RMDMD 291_ TPHCL 296_ TCPQQ 301_ STAES 306_ EGATI 311_ CTCES 316_ GHYRA 321_ PGEGP 326_ QVACT 331_ GPPSA 336_ PRNLS 341_ FSASG 346_ TQLSL 351_ RWEPP 356_ ADTGG 361_ RQDVR 366_ YSVRC 371_ SQCQG 376_ TAQDG 381_ GPCQP 386_ CGVGV 391_ HFSPG 396_ ARGLT 401_ TPAVH 406_ VNGLE 411_ PYANY 416_ TFNVE 421_ AQNGV 426_ SGLGS 431_ SGHAS 436_ TSVSI 441_ SMGHA 446_ ESLSG 451_ LSLRL 456_ VKKEP 461_ RQLEL 466_ TWAGS 471_ RPRSP 476_ GANLT 481_ YELHV 486_ LNQDE 491_ ERYQM 496_ VLEPR 501_ VLLTE 506_ LQPDT 511_ TYIVR 516_ VRMLT 521_ PLGPG 526_ PFSPD 531_ HEFRT 536_ SPPVS 541_ RGLTG 546_ GEIVA 551_ VIFGL 556_ LLGAA 561_ LLLGI 566_ LVFRS 571_ RRAQR 576_ QRQQR 581_ QRDRA 586_ TDVDR 591_ EDKLW 596_ LKPYV 601_ DLQAY 606_ EDPAQ 611_ GALDF 616_ TRELD 621_ PAWLM 626_ VDTVI 631_ GEGEF 636_ GEVYR 641_ GTLRL 646_ PSQDC 651_ KTVAI 656_ KTLKD 661_ TSPGG 666_ QWWNF 671_ LREAT 676_ IMGQF 681_ SHPHI 686_ LHLEG 691_ VVTKR 696_ KPIMI 701_ ITEFM 706_ ENGAL 711_ DAFLR 716_ EREDQ 721_ LVPGQ 726_ LVAML 731_ QGIAS 736_ GMNYL 741_ SNHNY 746_ VHRDL 751_ AARNI 756_ LVNQN 761_ LCCKV 766_ SDFGL 771_ TRLLD 776_ DFDGT 781_ YETQG 786_ GKIPI 791_ RWTAP 796_ EAIAH 801_ RIFTT 806_ ASDVW 811_ SFGIV 816_ MWEVL 821_ SFGDK 826_ PYGEM 831_ SNQEV 836_ MKSIE 841_ DGYRL 846_ PPPVD 851_ CPAPL 856_ YELMK 861_ NCWAY 866_ DRARR 871_ PHFQK 876_ LQAHL 881_ EQLLA 886_ NPHSL 891_ RTIAN 896_ FDPRM 901_ TLRLP 906_ SLSGS 911_ DGIPY 916_ RTVSE 921_ WLESI 926_ RMKRY 931_ ILHFH 936_ SAGLD 941_ TMECV 946_ LELTA 951_ EDLTQ 956_ MGITL 961_ PGHQK 966_ RILCS 971_IQGFK
1: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis