C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)
1_MDSFN 6_ YTTPD 11_ YGHYD 16_ DKDTL 21_ DLNTP 26_ VDKTS 31_ NTLRV 36_ PDILA 41_ LVIFA 46_ VVFLV 51_ GVLGN 56_ ALVVW 61_ VTAFE 66_ AKRTI 71_ NAIWF 76_ LNLAV 81_ ADFLS 86_ CLALP 91_ ILFTS 96_ IVQHH 101_ HWPFG 106_ GAACS 111_ ILPSL 116_ ILLNM 121_ YASIL 126_ LLATI 131_ SADRF 136_ LLVFK 141_ PIWCQ 146_ NFRGA 151_ GLAWI 156_ ACAVA 161_ WGLAL 166_ LLTIP 171_ SFLYR 176_ VVREE 181_ YFPPK 186_ VLCGV 191_ DYSHD 196_ KRRER 201_ AVAIV 206_ RLVLG 211_ FLWPL 216_ LTLTI 221_ CYTFI 226_ LLRTW 231_ SRRAT 236_ RSTKT 241_ LKVVV 246_ AVVAS 251_ FFIFW 256_ LPYQV 261_ TGIMM 266_ SFLEP 271_ SSPTF 276_ LLLKK 281_ LDSLC 286_ VSFAY 291_ INCCI 296_ NPIIY 301_ VVAGQ 306_ GFQGR 311_ LRKSL 316_ PSLLR 321_ NVLTE 326_ ESVVR 331_ ESKSF 336_ TRSTV 341_DTMAQ
1: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520)