Gene name: TBXA2R

Uniprot entry:

P21731

Protein names:

Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)

Protein sequence:

1_MWPNG 6_ SSLGP 11_ CFRPT 16_ NITLE 21_ ERRLI 26_ ASPWF 31_ AASFC 36_ VVGLA 41_ SNLLA 46_ LSVLA 51_ GARQG 56_ GSHTR 61_ SSFLT 66_ FLCGL 71_ VLTDF 76_ LGLLV 81_ TGTIV 86_ VSQHA 91_ ALFEW 96_ HAVDP 101_ GCRLC 106_ RFMGV 111_ VMIFF 116_ GLSPL 121_ LLGAA 126_ MASER 131_ YLGIT 136_ RPFSR 141_ PAVAS 146_ QRRAW 151_ ATVGL 156_ VWAAA 161_ LALGL 166_ LPLLG 171_ VGRYT 176_ VQYPG 181_ SWCFL 186_ TLGAE 191_ SGDVA 196_ FGLLF 201_ SMLGG 206_ LSVGL 211_ SFLLN 216_ TVSVA 221_ TLCHV 226_ YHGQE 231_ AAQQR 236_ PRDSE 241_ VEMMA 246_ QLLGI 251_ MVVAS 256_ VCWLP 261_ LLVFI 266_ AQTVL 271_ RNPPA 276_ MSPAG 281_ QLSRT 286_ TEKEL 291_ LIYLR 296_ VATWN 301_ QILDP 306_ WVYIL 311_ FRRAV 316_ LRRLQ 321_ PRLST 326_ RPRSL 331_ SLQPQ 336_LTQRS

Protein annotations

Protein functions:

1: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C

2: Activates adenylyl cyclase

3: Inhibits adenylyl cyclase