Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
1_MAVPP 6_ TYADL 11_ GKSAR 16_ DVFTK 21_ GYGFG 26_ LIKLD 31_ LKTKS 36_ ENGLE 41_ FTSSG 46_ SANTE 51_ TTKVT 56_ GSLET 61_ KYRWT 66_ EYGLT 71_ FTEKW 76_ NTDNT 81_ LGTEI 86_ TVEDQ 91_ LARGL 96_ KLTFD 101_ SSFSP 106_ NTGKK 111_ NAKIK 116_ TGYKR 121_ EHINL 126_ GCDMD 131_ FDIAG 136_ PSIRG 141_ ALVLG 146_ YEGWL 151_ AGYQM 156_ NFETA 161_ KSRVT 166_ QSNFA 171_ VGYKT 176_ DEFQL 181_ HTNVN 186_ DGTEF 191_ GGSIY 196_ QKVNK 201_ KLETA 206_ VNLAW 211_ TAGNS 216_ NTRFG 221_ IAAKY 226_ QIDPD 231_ ACFSA 236_ KVNNS 241_ SLIGL 246_ GYTQT 251_ LKPGI 256_ KLTLS 261_ ALLDG 266_ KNVNA 271_ GGHKL 276_GLGLE
1: Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784)
2: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids